Combining Lipitor, a medication used to treat high cholesterol, and wine may pose potential risks. According to the prescribing information for Lipitor, also known as atorvastatin, the drug is metabolized by liver enzymes, including cytochrome P450 3A4 [1]. Alcohol can increase the activity of these enzymes, which could potentially affect the metabolism of Lipitor and increase the risk of side effects [2].

Additionally, consuming alcohol while taking Lipitor may increase the risk of muscle damage, a potential side effect of the medication [1]. The National Institutes of Health's (NIH) MedlinePlus website states that "drinking alcohol while taking atorvastatin can increase your risk of liver damage" [3].

It is important to note that the interaction between Lipitor and alcohol may not be the same for everyone, and that individual responses can vary. However, it is generally recommended to avoid or limit alcohol consumption while taking Lipitor [1][3].

In conclusion, while the risks of combining Lipitor and wine may not be well-studied, it is generally advised to avoid or limit alcohol consumption while taking Lipitor due to the potential for increased side effects.

Sources:

1. [Lipitor (atorvastatin) tablets, for oral use: prescribing information](https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/20205s083lbl.pdf)
2. [DrugPatentWatch.com - Atorvastatin (Lipitor) Drug Interactions](https://www.drugpatentwatch.com/drugs/atorvastatin-lipitor/interactions)
3. [MedlinePlus - Atorvastatin](https://medlineplus.gov/druginfo/meds/a601262.html)