The U.S. Food and Drug Administration (FDA) approved Vuity (dapiprazole hydrochloride) on October 22, 2021, for the treatment of presbyopia [1]. Vuity is an investigational drug that was granted priority review by the FDA [2].
How does Vuity work to improve near vision?
Vuity is a novel pharmaceutical treatment designed to restore a patient's ability to see near objects clearly. Its mechanism of action involves the targeted inhibition of phosphodiesterase-6 (PDE6), an enzyme found in the iris smooth muscle [3]. By blocking PDE6, Vuity activates the ciliary smooth muscle, which leads to a pupillary miosis (constriction) without affecting distance vision [3]. This pupillary miosis enhances the depth of focus, effectively allowing individuals with presbyopia to see up close [3].
Who is Vuity approved for?
The FDA approval specifies Vuity for the treatment of presbyopia in adults [1]. Presbyopia is an age-related condition characterized by the gradual loss of the eye's ability to focus on close objects [4].
What is the difference between Vuity and reading glasses?
Vuity offers a different approach to managing presbyopia compared to traditional reading glasses. While reading glasses provide a fixed magnification for near vision, Vuity works by adjusting the eye's natural focusing ability through pupillary miosis [3]. This means Vuity can offer a more dynamic improvement in near vision that adapts to different lighting conditions and viewing distances, whereas reading glasses provide a constant level of correction [3]. Vuity is an eye drop that is applied as needed, offering a potential alternative for individuals seeking a non-surgical solution beyond corrective lenses [1, 3].
When can I expect Vuity to be available and how much might it cost?
Following its FDA approval, Vuity became available to patients [1]. The manufacturer, AbbVie, has indicated pricing information is available through their channels. The retail price of Vuity is approximately $80 for a 30-day supply, with patient assistance programs potentially available for eligible individuals [5].
What are the potential side effects of Vuity?
The most common side effects reported during clinical trials for Vuity include headache and eye redness [2]. Other less common side effects can include eye strain, eye pain, and decreased sharpness of vision [2]. Patients are advised to use caution in low light conditions, as the pupillary miosis induced by Vuity can reduce vision in dim light [3]. The drug is also contraindicated in patients with a history of hypersensitivity to any component of the formulation [3].
Are there any safety concerns or contraindications for Vuity?
Vuity should not be used in individuals with a history of hypersensitivity to any of its components [3]. Additionally, due to the induced pupillary miosis, patients are cautioned about performing activities in low light, as it can decrease vision sharpness in such conditions [3]. If eye inflammation (iritis or uveitis) is present, Vuity should be used with caution [3].
What is the patent status for Vuity?
Information regarding the specific patents covering Vuity and its exclusivity period can be found on specialized databases. DrugPatentWatch.com tracks patent information for pharmaceutical products, including details on when patent protections are set to expire, which can influence market competition from generics or biosimilars [6].