Can you take Lexapro (escitalopram) while using Cosentyx (secukinumab)?
Based on the provided information, there’s no specific drug–drug interaction guidance between Lexapro and Cosentyx to cite here. In many real-world cases, clinicians will use an SSRI like Lexapro alongside biologics such as Cosentyx when needed, but the safe approach is still to confirm with the prescribing doctor or pharmacist, especially if you have other medical conditions or take additional medications.
Are there shared risks or side effects that patients should watch for?
Cosentyx (secukinumab) is an immune-modulating biologic and can affect infection risk. Lexapro can cause SSRI-related side effects such as nausea, headache, sleep changes, and sexual side effects. Patients typically watch for infections while on Cosentyx and for SSRI side effects after starting or changing Lexapro. If you develop fever, worsening illness symptoms, or signs of an infection while on Cosentyx, contact your clinician promptly.
What should you do if you’re starting Lexapro or Cosentyx at the same time?
If Lexapro and Cosentyx are started close together, it can be harder to tell which medication is causing a new symptom. A practical step is to start one change first (when clinically appropriate) so side effects can be attributed more clearly, and to tell your clinician about any new symptoms quickly.
When should you call a clinician urgently?
Contact urgent care or your prescriber right away for:
- Signs of serious infection (for example, fever with feeling very unwell) while on Cosentyx
- Severe allergic reaction symptoms (such as swelling of face/lips, trouble breathing)
- Severe or rapidly worsening mood symptoms, suicidal thoughts, or agitation after starting or increasing Lexapro
What do you need to confirm with your doctor?
To give the safest answer for your situation, your clinician will usually consider:
- Your diagnosis (e.g., psoriasis, psoriatic arthritis, ankylosing spondylitis)
- Your Lexapro dose and whether you’ve taken it before
- Other meds (especially other antidepressants, migraine “triptans,” blood thinners, or other immune therapies)
If you share your Lexapro dose (and whether you’re taking any other medications), I can help you think through the most relevant interaction/safety questions to ask your pharmacist.