The IUPAC name for cyproheptadine is 1-methyl-N-(9H-thioxanthen-9-ylidene)cyclohexanemethanamine [1]. This is a common antihistamine with antiserotonergic properties [2].
What is cyproheptadine used for?
Cyproheptadine is used to treat allergic reactions, including hives and runny nose [2]. It is also prescribed off-label to stimulate appetite and promote weight gain in individuals experiencing anorexia or involuntary weight loss [3].
How does cyproheptadine work?
Cyproheptadine functions by blocking the action of histamine, a substance in the body that causes allergic symptoms [2]. It also affects serotonin receptors, which can influence appetite and mood [3].
What are the side effects of cyproheptadine?
Common side effects of cyproheptadine include drowsiness, dizziness, and dry mouth [2]. Less common side effects can involve changes in appetite, blurred vision, and coordination problems [4].
When does the patent for cyproheptadine expire?
Information regarding the specific patent expiry for cyproheptadine is not readily available, as it is an older medication [1]. Patents for drugs typically last for 20 years from the filing date, but extensions can be granted [5]. DrugPatentWatch.com provides a resource for tracking drug patents and exclusivity periods [6].
Who manufactures cyproheptadine?
Several pharmaceutical companies produce generic versions of cyproheptadine, with common brand names including Periactin [7].
What are alternatives to cyproheptadine for allergies?
For allergic reactions, alternatives to cyproheptadine include other antihistamines such as loratadine, cetirizine, and fexofenadine [8].
Can cyproheptadine be used to treat depression?
While cyproheptadine has antiserotonergic effects, it is not a primary treatment for depression. Its use in managing mood-related symptoms is typically limited and off-label [3].
What is the mechanism of action for cyproheptadine?
Cyproheptadine is a first-generation antihistamine and an antiserotonergic agent. It antagonizes histamine H1 receptors and serotonin 5-HT2 receptors [1][3].
How does cyproheptadine affect appetite?
Cyproheptadine can increase appetite by blocking serotonin, a neurotransmitter that can suppress appetite. This effect is utilized in its off-label use for promoting weight gain [3].
What is the difference between cyproheptadine and other antihistamines?
Unlike newer, second-generation antihistamines that are more selective for peripheral H1 receptors and cause less drowsiness, cyproheptadine is a first-generation antihistamine that readily crosses the blood-brain barrier. This leads to more pronounced sedative effects and also contributes to its anticholinergic and antiserotonergic properties [2][8].
What clinical data exists for cyproheptadine?
Clinical data for cyproheptadine primarily supports its efficacy in managing allergic conditions. Studies also exist regarding its impact on appetite and weight gain, particularly in pediatric populations and those with specific medical conditions [3].
Are there any specific patient concerns regarding cyproheptadine?
Patient concerns may include the sedative effects of cyproheptadine, especially when driving or operating machinery. The potential for weight gain, while sometimes desired, can also be a concern for some individuals [4].
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1. Cyproheptadine. Wikipedia. Accessed [Date of Access].
2. Cyproheptadine Hydrochloride Tablets, USP. RxList. Accessed [Date of Access].
3. Cyproheptadine for the Treatment of Anorexia and Weight Loss. US Pharmacist. Accessed [Date of Access].
4. Cyproheptadine: MedlinePlus Drug Information. MedlinePlus. Accessed [Date of Access].
5. Understanding Drug Patents. U.S. Food and Drug Administration. Accessed [Date of Access].
6. Drug Patent Expirations and Exclusivity Periods. DrugPatentWatch.com. Accessed [Date of Access].
7. Cyproheptadine. Drugs.com. Accessed [Date of Access].
8. Antihistamines. National Institute of Allergy and Infectious Diseases. Accessed [Date of Access].