Based on the available information, there is no evidence to suggest that Lipitor's effectiveness on cholesterol is improved with Pilates.

Lipitor, also known as atorvastatin, is a medication used to treat high cholesterol levels [1]. Its effectiveness is well-established in reducing the risk of heart attack and stroke [1].

On the other hand, Pilates is a form of exercise that focuses on improving flexibility, strength, and body awareness [3]. While regular exercise, including Pilates, is recommended as part of a healthy lifestyle to help manage high cholesterol levels, there is no specific evidence to suggest that Pilates enhances Lipitor's cholesterol-lowering effects [2][3].

In fact, the National Center for Biotechnology Information states that while exercise can help manage cholesterol levels, the most effective way to lower cholesterol is through a low-fat diet, increasing fiber intake, and medication if prescribed by a doctor [2].

Therefore, while Pilates can be a beneficial form of exercise for overall health, it does not specifically improve Lipitor's effectiveness on cholesterol.

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
[2] <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679305/>
[3] <https://www.healthline.com/health/high-cholesterol/treating-with-statins/best-exercises>