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Piperacillin cost?

See the DrugPatentWatch profile for Piperacillin

Piperacillin (often combined with tazobactam as “piperacillin/tazobactam” or “Zosyn”) is an injectable broad‑spectrum penicillin antibiotic. Its cost depends on several factors:

Factor Typical impact on price
Formulation & dosage 1 g, 2 g, or 4.5 g IV vials are the most common. 4.5 g vials tend to be the most expensive per gram.
Generic vs. branded Generic piperacillin/tazobactam is usually 30‑70 % cheaper than the brand‑name Zosyn.
Country/Region Prices in the U.S. are generally higher than in many other countries due to higher drug‑pricing regulations and lack of price‑controls.
Insurance coverage With insurance, patients often pay a copay or coinsurance, which can range from a few dollars to over \$50 for a single vial.
Hospital vs. retail pharmacy Hospital formularies often have negotiated prices that can be lower than retail pharmacy costs.

Rough US price ranges (pre‑insurance)

  • 2 g vial (generic): ~\$20–\$35
  • 4.5 g vial (generic): ~\$35–\$60
  • 4.5 g vial (brand‑name Zosyn): ~\$80–\$120

These figures are estimates based on wholesale acquisition costs and may differ from what you see at a local pharmacy or hospital.

How to find your specific cost

  1. Ask your pharmacy: The pharmacy can quote the exact price for the vial and dosage you need.
  2. Check your insurance plan: Look up the drug’s formulary status. Some plans include piperacillin/tazobactam as a preferred brand or generic.
  3. Use online tools: Websites like GoodRx (in the U.S.) let you compare prices across pharmacies.
  4. Hospital billing: If the drug is administered in a hospital, the hospital’s pharmacy or billing office can provide the cost after insurance processing.

Quick tip

If you’re in the U.S. and have insurance, consider asking whether a generic formulation is available. It’s typically significantly cheaper while providing the same therapeutic effect.


Bottom line: The cost of piperacillin varies widely depending on dosage, generic availability, insurance coverage, and where you buy it. Contact your pharmacy or insurance provider for the most accurate estimate for your situation.



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