Can Cosentyx (secukinumab) raise liver enzymes?
Cosentyx (secukinumab) can be associated with liver enzyme elevations. In drug safety information, liver test abnormalities (including increased transaminases) are listed among potential side effects, so clinicians may monitor liver enzymes in people who develop symptoms of liver problems or who have other liver risk factors [1].
What liver enzyme changes are reported?
The main concern is an increase in liver enzymes such as ALT and AST (transaminases). These lab changes are typically detected on routine or symptom-triggered bloodwork rather than being something people can feel directly [1].
Who should be more careful or get monitored?
People with known liver disease, a history of hepatitis, or other risk factors for liver injury may need closer monitoring while on Cosentyx. Monitoring is also more important if you develop symptoms that can suggest liver injury (for example, jaundice, dark urine, unusual fatigue, or right upper belly pain) [1].
What symptoms mean you should stop and call a clinician?
If you notice symptoms consistent with liver injury, contact your prescriber promptly and get liver tests. Seek urgent care if symptoms are severe (for example, yellowing of the skin/eyes or significant weakness) [1].
What else could raise liver enzymes while on Cosentyx?
Liver enzyme elevations can have many causes besides Cosentyx, including viral infections, alcohol-related liver injury, fatty liver disease, and other medications or supplements people take. Your clinician will usually consider timing, other drugs, alcohol use, and viral hepatitis risk when evaluating elevated results [1].
Does this show up in official safety listings?
Yes. Drug labeling and safety resources include liver enzyme abnormalities as potential adverse effects for Cosentyx, which is why monitoring may be recommended in appropriate situations [1].
Sources:
[1] https://www.drugpatentwatch.com/