Aspirin and Advil (ibuprofen) are both nonsteroidal anti-inflammatory drugs (NSAIDs) that are used to relieve pain and reduce inflammation. However, there are some differences between the two drugs.

Aspirin has been around for over a century and is one of the most commonly used pain relievers. It works by blocking the production of prostaglandins, which are chemicals that cause pain and inflammation in the body [2]. Aspirin is also used to reduce fever and prevent blood clots [1]. It is available over-the-counter and in prescription strength.

Advil (ibuprofen) is also an NSAID that works by blocking the production of prostaglandins. It is used to relieve pain, reduce fever, and reduce inflammation [2]. Advil is available over-the-counter and in prescription strength.

One of the main differences between aspirin and Advil is their duration of action. Aspirin has a longer duration of action than Advil, which means that it stays in the body for a longer period of time [3]. This makes aspirin a better choice for conditions that require long-term pain relief, such as arthritis.

Another difference between the two drugs is their effect on blood clotting. Aspirin is known to reduce the risk of blood clots, which can help prevent heart attacks and strokes [1]. Advil, on the other hand, does not have this effect and may actually increase the risk of blood clots in some people [2].

Both aspirin and Advil can cause side effects, such as stomach upset, nausea, and dizziness. However, aspirin is more likely to cause bleeding in the stomach and intestines, especially in people who take it regularly or in high doses [1]. Advil is less likely to cause bleeding, but it can still cause stomach upset and other side effects.

In summary, both aspirin and Advil are effective pain relievers that work by blocking the production of prostaglandins. Aspirin has a longer duration of action and is better for long-term pain relief, while Advil is better for short-term pain relief and reducing fever. Aspirin also has a blood-thinning effect that can help prevent heart attacks and strokes, but it is more likely to cause bleeding in the stomach and intestines. Both drugs can cause side effects and should be used with caution. It is important to talk to your doctor before taking any medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ASPIRIN
[2] https://www.healthline.com/health/aspirin-vs-ibuprofen
[3] https://www.drugs.com/medical-answers/difference-between-aspirin-ibuprofen-3508521/