Should tigecycline be refrigerated or stored at room temperature?

Official Storage Instructions for Tigecycline

Tigecycline (Tygacil), an IV antibiotic, requires refrigeration during storage. The manufacturer recommends storing unopened vials at 2°C to 8°C (36°F to 46°F) in a refrigerator. Do not freeze.[1][2]

After Reconstitution and Dilution

Once reconstituted with 5.3 mL of 0.9% sodium chloride or dextrose, the solution is stable at room temperature (up to 25°C or 77°F) for up to 24 hours if protected from light. For longer stability (up to 48 hours), refrigerate the diluted solution at 2°C to 8°C. Inspect for particulate matter before use and discard if present.[1][3]

Why Refrigeration Matters

Heat or improper storage can degrade tigecycline, reducing potency against resistant bacteria like MRSA or Acinetobacter. Hospitals follow these guidelines to maintain efficacy during shortages or transport.[2][4]

Common Handling Questions

• Can it be left out briefly? Yes, short excursions to room temperature are allowed per USP <1079>, but return to refrigeration promptly.
  
• Freezing risk? Avoid; thawing may cause precipitation.
  
• Expiration after mixing? Use within 6 hours at room temperature or 24-48 hours refrigerated, depending on diluent.[1]
  
  [1]: Tygacil Prescribing Information (Pfizer)
  [2]: FDA Drug Label for Tygacil
  [3]: ASHP Injectable Drug Information
  [4]: CDC Antibiotic Storage Guidelines