Entresto is a medication used to treat certain types of heart failure [1]. It is prescribed for patients with symptomatic chronic heart failure with reduced ejection fraction [2].
How does Entresto work?
Entresto is a combination medication that contains sacubitril and valsartan [1]. Sacubitril is a neprilysin inhibitor, and valsartan is an angiotensin II receptor blocker (ARB) [1][3]. This dual action helps to relax blood vessels, reduce sodium and fluid buildup, and decrease the workload on the heart [3].
When did Entresto become available?
Entresto was approved by the U.S. Food and Drug Administration (FDA) in July 2015 [4].
What is the generic name for Entresto?
The generic name for Entresto is sacubitril/valsartan [1].
How does Entresto compare to other heart failure medications?
Studies have shown that Entresto is more effective than an ACE inhibitor (enalapril) in reducing cardiovascular death and heart failure hospitalizations in patients with chronic heart failure with reduced ejection fraction [2][5]. It is often considered a preferred treatment option for eligible patients [5].
When does the patent for Entresto expire?
The patent landscape for Entresto is complex and involves multiple patents. According to DrugPatentWatch.com, key patents related to Entresto are set to expire in the coming years, with some anticipated to expire around 2029 [6]. However, the exact timing of generic availability can be influenced by various legal and regulatory factors [6].
Can generic versions of Entresto be made?
Once patents expire and regulatory approval is obtained, generic versions of sacubitril/valsartan can be manufactured and marketed [6]. This typically leads to lower medication costs [6].
What are the side effects of Entresto?
Common side effects of Entresto can include low blood pressure, high potassium levels, dizziness, cough, and kidney problems [1]. Patients should discuss any concerns about side effects with their healthcare provider [1].
What is the cost of Entresto?
The cost of Entresto can vary depending on insurance coverage, pharmacy, and dosage [7]. Patients may find assistance programs or coupons offered by the manufacturer [7]. Generic versions, when available, are generally less expensive [6].
Sources:
[1] https://www.entresto.com/
[2] https://www.nejm.org/doi/full/10.1056/NEJMoa1409537
[3] https://www.heart.org/en/health-topics/heart-failure/treatment-options-for-heart-failure/entresto-sacubitril-valsartan
[4] https://www.fda.gov/drugs/drug-approvals-and-databases/drug-approvals-and-certifications
[5] https://www.acc.org/latest-in-cardiology/articles/2022/11/15/10/35/the-2022-accaha-guideline-for-the-management-of-heart-failure-keys-to-understanding-the-updates
[6] https://www.drugpatentwatch.com/p/23505/entresto
[7] https://www.goodrx.com/entresto