How is Xyosted administered?
Xyosted, a weekly auto-injector for testosterone enanthate, is injected subcutaneously into the fat layer of the abdomen, not into the muscle. Users pinch the skin, insert the needle at a 45- or 90-degree angle, and press to deliver the dose.[1][2]
Why subcutaneous instead of intramuscular?
Subcutaneous injection allows slow, steady absorption of the oil-based testosterone, mimicking natural hormone release and reducing injection-site reactions compared to intramuscular shots. Intramuscular is common for other testosterone forms like Depo-Testosterone, but Xyosted's design targets fatty tissue for convenience and tolerability.[1][3]
Where exactly on the body?
Inject only into the abdomen, at least 2 inches from the belly button. Rotate sites weekly to avoid irritation. Do not use arms, thighs, or buttocks.[1][2]
What if injected into muscle by mistake?
It may still absorb but could cause more pain or uneven release. Follow instructions to stay subcutaneous; consult a doctor if unsure or if severe pain/swelling occurs.[2]
Xyosted vs. other testosterone injections
| Product | Injection Type | Site | Frequency |
|---------|---------------|------|-----------|
| Xyosted | Subcutaneous | Abdomen | Weekly |
| Depo-Testosterone | Intramuscular | Glutes/thigh | 2-4 weeks |
| Aveed | Intramuscular | Glutes | 10 weeks |
Xyosted simplifies self-administration for hypogonadism patients.[3]
[1]: Xyosted Prescribing Information (Antares Pharma)
[2]: FDA Label for Xyosted
[3]: Drugs.com - Xyosted