See the DrugPatentWatch profile for Hadlima
Hadlima is a biosimilar to the drug adalimumab [1]. It is used to treat several inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, and plaque psoriasis [2].
What are Hadlima's approved uses?
Hadlima is approved for the treatment of moderate to severe rheumatoid arthritis in adults, psoriatic arthritis in adults, ankylosing spondylitis in adults, moderately to severely active Crohn's disease in adults and pediatric patients (6 years and older), moderately to severely active ulcerative colitis in adults and pediatric patients (6 years and older), and chronic, moderate to severe plaque psoriasis in adults and pediatric patients (4 years and older) who are candidates for systemic therapy or phototherapy [2].
How does Hadlima work?
Hadlima is a tumor necrosis factor (TNF) blocker. It works by binding to TNF, a protein that plays a role in inflammation, thereby reducing inflammation in the body [1, 2].
When does the patent for adalimumab (Humira) expire?
The reference product for Hadlima is adalimumab, commonly known by the brand name Humira. Patents protecting Humira have expired, allowing biosimilar versions like Hadlima to enter the market [3]. DrugPatentWatch.com tracks patent expirations for many drugs, including adalimumab [3].
Who manufactures Hadlima?
Hadlima is manufactured by Samsung Bioepis [4].
How does Hadlima compare to other adalimumab biosimilars?
Several biosimilar versions of adalimumab are available, including Hadlima. These biosimilars are designed to be highly similar to Humira in terms of safety, efficacy, and quality, offering potentially lower-cost treatment options [1, 3]. Other adalimumab biosimilars include Amjevita, Cyltezo, Hyrimoz, Idacio, and Yuflyma, among others [4].
What are the potential side effects of Hadlima?
Like other TNF blockers, Hadlima can cause serious side effects, including serious infections, an increased risk of certain cancers, allergic reactions, and neurological problems. Common side effects may include upper respiratory tract infections, sinus infections, rash, and pain [2]. Patients should discuss potential risks with their healthcare provider.