Risperdal (risperidone) was first launched in the U.S. market in 1993 [1][2]. It is an atypical antipsychotic medication [3].
When did Risperdal go generic in the US?
The patent exclusivity for risperidone expired, leading to the availability of generic versions. The first generic risperidone tablets became available in the U.S. in late 2008 [4][5]. This made the medication more accessible and affordable for patients [4].
What is risperidone used to treat?
Risperidone is prescribed to treat a range of mental health conditions. These include schizophrenia and schizoaffective disorder in adults and adolescents [3]. It is also used to manage symptoms of bipolar I disorder in adults and children aged 10 years and older, specifically for manic or mixed episodes [3]. Additionally, risperidone can be used to treat irritability associated with autistic disorder in children aged 5 to 16 years [3].
How does risperidone work?
Risperidone functions by altering the effects of certain chemicals in the brain, known as neurotransmitters [3]. Specifically, it acts as a dopamine and serotonin antagonist [3]. By balancing these neurotransmitters, it helps to reduce or manage the symptoms of the conditions it is prescribed for, such as hallucinations, delusions, and disorganized thinking [3].
Who makes Risperdal?
The original manufacturer of Risperdal in the United States was Janssen Pharmaceutica, a subsidiary of Johnson & Johnson [2][6]. Following patent expirations, numerous other pharmaceutical companies now produce and market generic versions of risperidone [4].
What are the potential side effects of risperidone?
Common side effects associated with risperidone can include drowsiness, dizziness, weight gain, and dry mouth [3]. More serious side effects, though less common, may include involuntary movements (tardive dyskinesia), high blood sugar, and changes in cholesterol levels [3]. Patients are advised to discuss any concerns about side effects with their healthcare provider [3].
Can I switch from brand-name Risperdal to a generic?
Switching from brand-name Risperdal to a generic risperidone product is generally permissible once generic versions are available [4]. Generic medications are required to contain the same active ingredient and be bioequivalent to their brand-name counterparts [4]. However, it is always recommended to consult with a doctor or pharmacist before making any switch to ensure it is appropriate for an individual's treatment plan [3][4].
What is the difference between risperidone and paliperidone?
Paliperidone is the active metabolite of risperidone [7]. This means that after risperidone is taken, the body converts it into paliperidone [7]. Consequently, paliperidone has a similar pharmacological profile and is used to treat the same conditions as risperidone [7]. Paliperidone is marketed under brand names such as Invega [7].
Sources:
[1] https://www.drugpatentwatch.com/
[2] https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020272s038,020708s017,021145s015lbl.pdf
[3] https://medlineplus.gov/druginfo/meds/a694016.html
[4] https://www.fda.gov/drugs/generic-drugs
[5] https://www.drugpatentwatch.com/risperidone-patent-expiration-and-generic-launch-date/
[6] https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=history.page&ApplNo=020272
[7] https://www.drugbank.ca/drugs/paliperidone