Trulance (also known as C-1045) is a drug used to treat adults with active non-radiographic axial spondyloarthritis (nr-axSpA) who have had an inadequate response or intolerance to at least one nonsteroidal anti-inflammatory drug (NSAID) [1][2]. It is also indicated for the treatment of adults with active psoriatic arthritis (PsA) who have had an inadequate response or intolerance to at least one biologic or biomimetic disease-modifying antirheumatic drug (bDMARD) [1][2].
How does Trulance work?
Trulance is a selective inhibitor of Janus kinase (JAK) 1 and JAK 2 [1][3]. By inhibiting these enzymes, Trulance modulates the signaling pathways of cytokines involved in inflammation and immune responses, which are implicated in conditions like axial spondyloarthritis and psoriatic arthritis [3].
When did Trulance receive approval?
The U.S. Food and Drug Administration (FDA) approved Trulance for the treatment of active psoriatic arthritis in December 2021 [2]. Approval for active non-radiographic axial spondyloarthritis followed in June 2023 [1].
What are the potential side effects of Trulance?
Common side effects of Trulance include upper respiratory tract infections, headaches, and diarrhea [2]. Serious side effects can involve blood clots, heart attack, stroke, increased risk of death, serious infections, and certain cancers [2]. Patients taking Trulance may also experience changes in certain laboratory test results [2].
How does Trulance compare to other treatments for PsA and nr-axSpA?
Trulance belongs to a class of drugs called JAK inhibitors, which offer an alternative to biologic therapies for psoriatic arthritis and non-radiographic axial spondyloarthritis [1][2]. Other treatment options include NSAIDs, conventional synthetic DMARDs, and other classes of biologics such as TNF inhibitors, IL-17 inhibitors, and IL-12/23 inhibitors [4][5]. The choice of treatment depends on individual patient factors, disease severity, and response to previous therapies.
What is the prescribing information for Trulance?
Prescribing information for Trulance details its indications, dosage, administration, contraindications, warnings, precautions, adverse reactions, and drug interactions [1][2]. It is essential for healthcare providers to review this information thoroughly before prescribing the medication. Patients should also discuss any questions or concerns with their doctor.
Are there any contraindications for Trulance?
Trulance is contraindicated in patients with known hypersensitivity to tralokinumab or any of its excipients [2]. It is also not recommended in patients with active serious infections [2].