Common Side Effects of Stelara
Stelara (ustekinumab), used for psoriasis, Crohn's disease, and ulcerative colitis, commonly causes upper respiratory infections, headache, and fatigue. Patients often report joint pain, diarrhea, back pain, or injection site reactions like redness and itching.[1][2]
Serious Side Effects and Warnings
Serious risks include infections such as tuberculosis or fungal infections, which can be fatal—screening is required before starting. It may increase cancer risk, including skin cancer, and worsen inflammatory bowel disease. Allergic reactions (rash, swelling, breathing trouble), reversible posterior leukoencephalopathy syndrome (RPLS), and hypersensitivity vasculitis are possible. Avoid live vaccines during treatment.[1][2][3]
Side Effects by Condition Treated
- Psoriasis: Nasopharyngitis, headache, pruritus most frequent; depression and serious infections less common.
- Crohn's/ulcerative colitis: Infections rise with infusions; abdominal pain, vomiting noted in trials.[2]
Long-Term Risks and Monitoring
Long-term use links to malignancies (e.g., 0.7% rate in trials vs. 0.3% placebo) and serious infections (3.4% vs. 2.1%). Regular TB tests, blood work, and skin checks are standard. Discontinue if active infection occurs.[1][3]
Patient-Reported Concerns
Forums highlight fatigue, hair loss, weight gain, and shingles outbreaks not always listed in trials. Some experience mood changes or worsened joint issues post-treatment.[2]
[1]: Stelara Prescribing Information (FDA)
[2]: Drugs.com - Stelara Side Effects
[3]: Mayo Clinic - Ustekinumab