What side effects can Augtyro (repotrectinib) cause?
The side effects reported for Augtyro (repotrectinib) include:
Common side effects
Patients may experience:
- Nausea
- Diarrhea
- Vomiting
- Fatigue
- Constipation
- Dizziness
- Dry mouth
Less common but important side effects
More serious reactions can include:
- Changes in blood counts (like anemia or low white blood cells)
- Liver enzyme elevations (abnormal liver function tests)
- Irregular heart rhythm (including QT prolongation)
- Neurologic effects such as confusion or coordination problems
- Swelling (edema)
When should patients call a clinician urgently?
Seek urgent medical care if you develop symptoms that could signal a serious drug reaction, such as:
- Fainting, severe dizziness, or chest palpitations (possible heart rhythm issue)
- Yellowing of skin/eyes or dark urine (possible liver problems)
- Severe or persistent vomiting/diarrhea causing dehydration
- New confusion, severe headache, or major changes in walking/coordination
Are there different side effects for different cancer types or dose changes?
Side effects can vary by patient and by dose, especially if a clinician reduces the dose due to tolerability. Heart-related effects (like QT prolongation) and liver lab changes are often monitored closely when patients start treatment or when doses are adjusted.
What about drug interactions that worsen side effects?
Repotrectinib can interact with other medicines, including drugs that affect liver enzymes and drug transporters. Those interactions can raise repotrectinib exposure and increase the risk of adverse effects such as fatigue, dizziness, or heart rhythm changes. Patients should ask their oncologist/pharmacist to check their full medication list.
Sources: None provided with your question.