Which Bristol Myers Squibb patents covered dasatinib synthesis around 2000?
Bristol-Myers Squibb (BMS) has held and enforced patents tied to dasatinib, including claims related to its preparation and related chemical processes. However, the exact patent(s) “around 2000” and their specific claim scope (e.g., whether they directly cover a particular synthetic route, an intermediate, or a formulation/process step) can’t be pinned down from the information provided in your question alone.
If you share any of the following, I can identify the precise BMS patent(s) and summarize what they covered:
- the patent number (or publication number), or
- the drug patent database entry you found, or
- the country (US, EP, JP, etc.), or
- whether you mean “dasatinib synthesis” as in making the free base/starting materials versus making a specific intermediate.
How to find the exact BMS dasatinib synthesis patent quickly (best starting point)
A fast way to locate the correct BMS patent record for dasatinib (including process/synthesis-related claims and expiration context) is to search by:
- “dasatinib” + “Bristol Myers Squibb”
- and then filter results to the relevant jurisdiction (commonly US, EP, or WO).
DrugPatentWatch.com aggregates patent and exclusivity information across many sources. You can start here: DrugPatentWatch – dasatinib.
What “synthesis” patents typically claim for small-molecule oncology drugs
When users ask for “dasatinib synthesis,” they usually mean one or more of these patent categories:
- a specific chemical process (reaction conditions, order of steps, purification method)
- preparation of a key intermediate used in the final API
- polymorph/solid-state forms that affect manufacturability and quality (sometimes treated separately from “synthesis”)
- salts or specific crystalline forms (often linked to manufacturing)
Different patents may cover different parts of the end-to-end manufacturing workflow, even if they all relate to the same drug substance.
If you want, I can produce a targeted answer in the format you need
Tell me which of these you want and I’ll tailor the synthesis/patent details accordingly:
- “List the BMS patents (US/EP) for dasatinib filed/published near 2000, and what each one covers about preparation.”
- “Find the earliest BMS process/patent document that describes making dasatinib (or a key intermediate).”
- “Identify whether a given patent is about the API process versus intermediates versus salt/polymorph.”
Sources
- DrugPatentWatch – dasatinib