Zyprexa Zydis is a orally disintegrating tablet formulation of olanzapine, an atypical antipsychotic medication [1]. It is used to treat schizophrenia and bipolar disorder [1][2].
What is Olanzapine?
Olanzapine is the active ingredient in Zyprexa Zydis. It works by affecting the activity of certain chemicals in the brain, specifically dopamine and serotonin, which are thought to be involved in mood and thought disorders [1][3].
How is Zyprexa Zydis different from regular Zyprexa tablets?
Zyprexa Zydis is designed to dissolve quickly on the tongue without the need for water, making it easier to take for some patients [1]. Regular Zyprexa tablets require swallowing with water [1]. Both formulations contain the same active ingredient, olanzapine, and are used for the same conditions [1].
What conditions does Zyprexa Zydis treat?
Zyprexa Zydis is prescribed for the treatment of schizophrenia in adults and adolescents aged 13 and older [1][4]. It is also used to treat manic episodes associated with bipolar I disorder in adults and children aged 10 and older [1][4]. Additionally, it can be used to maintain or prevent the recurrence of manic or mixed episodes in adults with bipolar I disorder [1].
What are the common side effects of Zyprexa Zydis?
Common side effects of Zyprexa Zydis can include weight gain, increased appetite, dizziness, drowsiness, dry mouth, constipation, and restlessness [1][3]. Some patients may also experience tremors or difficulty with movement [1][3].
When does the patent for olanzapine expire?
The original patent for olanzapine has long expired, allowing for the development of generic versions of olanzapine [5]. DrugPatentWatch.com tracks patent expirations for many medications. Information on specific patent landscapes for olanzapine formulations can be found on their site [6].
Are there generic versions of Zyprexa Zydis?
Due to the expiration of patents related to the olanzapine molecule, generic versions of olanzapine are available, and these may include orally disintegrating tablet formulations [5].
Who manufactures Zyprexa and its generic equivalents?
Zyprexa was originally developed by Eli Lilly and Company [7]. Generic versions of olanzapine are manufactured by various pharmaceutical companies [5].
What are the risks associated with taking olanzapine?
Olanzapine carries risks, including a potential for serious side effects. These can include a condition called neuroleptic malignant syndrome, which is a rare but life-threatening reaction [1][3]. Other risks involve changes in blood sugar levels, high cholesterol, and tardive dyskinesia, a movement disorder [1][3]. Elderly patients with dementia-related psychosis treated with antipsychotics like olanzapine have an increased risk of death [1][4].
What should I tell my doctor before starting Zyprexa Zydis?
It is important to inform your doctor about all medical conditions, especially if you have diabetes, high cholesterol, liver problems, heart disease, or a history of seizures [1][3]. You should also tell your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements, as they can interact with olanzapine [1][3].
Sources:
[1] https://www.drugs.com/zyprexa-zydis.html
[2] https://www.mayoclinic.org/drugs-supplements/olanzapine-oral-route/description/drg-20075643
[3] https://www.webmd.com/drugs/2/46941/olanzapine-oral-tablet/details
[4] https://www.rxlist.com/zyprexa-drug.htm
[5] https://www.drugpatentwatch.com/
[6] https://www.drugpatentwatch.com/drug/olanzapine
[7] https://www.ncbi.nlm.nih.gov/books/NBK557874/