Lyrica and melatonin are two different medications used for different purposes. Lyrica is a prescription medication used to treat nerve pain, seizures, and anxiety disorders. Melatonin, on the other hand, is a hormone that regulates sleep and wakefulness.

According to Drug Patent Watch [1], the recommended dose of Lyrica varies depending on the condition being treated. For neuropathic pain, the recommended starting dose is 50 mg three times a day, which can be increased to 100 mg three times a day after one week. For seizures, the recommended starting dose is 75 mg twice a day, which can be increased to 150 mg twice a day after one week. For anxiety disorders, the recommended starting dose is 75 mg twice a day, which can be increased to 150 mg twice a day after one week.

Melatonin is available over the counter and the recommended dose varies depending on the individual's needs. According to UpToDate [2], the recommended dose for insomnia in adults is 0.3 to 5 mg taken 30 minutes before bedtime. However, it is important to note that the optimal dose may vary depending on factors such as age, weight, and the severity of the sleep disorder.

It is important to note that Lyrica and melatonin have different mechanisms of action and are used for different purposes. While Lyrica is used to treat nerve pain, seizures, and anxiety disorders, melatonin is used to regulate sleep and wakefulness. Therefore, it is not necessary to take these medications together unless prescribed by a healthcare professional.

According to a study published in the Journal of Clinical Psychopharmacology [3], the combination of Lyrica and melatonin did not result in any significant drug interactions or adverse effects. However, it is important to consult with a healthcare professional before taking these medications together to ensure that it is safe and appropriate for your individual needs.

In summary, the recommended dose of Lyrica varies depending on the condition being treated, while the recommended dose of melatonin varies depending on the individual's needs. These medications have different mechanisms of action and are used for different purposes. It is important to consult with a healthcare professional before taking these medications together to ensure that it is safe and appropriate for your individual needs.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LYRICA
[2] https://www.uptodate.com/contents/pharmacotherapy-for-insomnia-in-adults
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340395/