Nexlizet, a combination therapy for high cholesterol, is not yet available in generic form. The drug combines bempedoic acid and ezetimibe. As of now, there is no generic equivalent for the branded Nexlizet.
When might a Nexlizet generic become available?
The availability of generic versions of drugs is typically tied to patent expirations and the successful navigation of regulatory pathways by generic manufacturers. Information on specific patent expiration dates for Nexlizet and ongoing legal challenges that could impact generic entry can be found on specialized databases like DrugPatentWatch.com [1].
What is Nexlizet used for?
Nexlizet is prescribed to lower LDL cholesterol levels in adults. It is typically used when statins alone are insufficient or not tolerated. The drug works by combining the mechanisms of bempedoic acid, which inhibits cholesterol synthesis, and ezetimibe, which reduces cholesterol absorption in the intestine [2].
What are the components of Nexlizet?
Nexlizet is composed of two active pharmaceutical ingredients: bempedoic acid and ezetimibe [2]. Bempedoic acid is a first-in-class ATP citrate lyase (ACL) inhibitor, while ezetimibe is a cholesterol absorption inhibitor.
Can you get bempedoic acid or ezetimibe separately?
Yes, bempedoic acid is available as a standalone medication under the brand name Nexletol. Ezetimibe is also available as a generic medication, and was previously marketed under the brand name Zetia [3]. Patients may be taking these components individually or in combination depending on their treatment plan.
How does Nexlizet compare to other cholesterol medications?
Nexlizet offers a dual mechanism of action for lowering LDL cholesterol. It can be used in addition to statins or as an alternative for patients who cannot tolerate statins. Other cholesterol-lowering treatments include statins, PCSK9 inhibitors, bile acid sequestrants, and fibrates, each with different mechanisms and indications [4].
What are the side effects of Nexlizet?
Common side effects associated with Nexlizet include upper respiratory tract infections, muscle spasms, back pain, abdominal discomfort or pain, bronchitis, and increased blood uric acid levels [2]. Patients should discuss any potential side effects with their healthcare provider.
What is the regulatory status of Nexlizet?
Nexlizet is approved by the U.S. Food and Drug Administration (FDA) for the treatment of adults with high cholesterol [2]. The drug is marketed by Esperion Therapeutics.
Who manufactures Nexlizet?
Nexlizet is manufactured by Esperion Therapeutics [5].
Sources:
[1] https://drugpatentwatch.com/
[2] https://www.nexlizet.com/
[3] https://www.goodrx.com/ezetimibe
[4] https://www.heart.org/en/health-topics/cholesterol/treatment-and-prevention-of-high-cholesterol
[5] https://www.esperion.com/