Lipitor is a medication used to lower cholesterol levels and prevent heart disease [1]. Grapefruit juice is known to interact with Lipitor and other statins, which can increase the risk of side effects [2]. The juice contains compounds that interfere with the enzymes responsible for breaking down the drug in the body. This can cause Lipitor to build up in the bloodstream, leading to higher levels of the medication than intended and potentially causing adverse effects.

The interaction between Lipitor and grapefruit juice can cause muscle pain, weakness, and damage, which can be severe and lead to a condition called rhabdomyolysis [3]. This condition can cause kidney damage and even kidney failure in some cases. Other possible side effects of the interaction between Lipitor and grapefruit juice include dizziness, headache, and stomach upset.

It is recommended that patients taking Lipitor avoid consuming grapefruit juice or any other grapefruit products, including whole grapefruit and grapefruit supplements [2]. Patients should also talk to their healthcare provider about any other medications or supplements they are taking, as they may also interact with Lipitor and increase the risk of side effects.

In conclusion, the risks of mixing Lipitor and grapefruit juice include an increased risk of side effects, such as muscle pain, weakness, and damage, and the potential for severe complications like rhabdomyolysis. Patients taking Lipitor should avoid consuming grapefruit products and talk to their healthcare provider about any other medications or supplements they are taking [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin
[3] https://ro.co/health-guide/lipitor-and-grapefruit/