There is currently no definitive scientific evidence to suggest that the regular use of Advil (ibuprofen), a non-prescription nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation [1], has a significant impact on the efficacy of antidepressants.

A study published in the Journal of Clinical Psychiatry in 2018 examined the potential interaction between NSAIDs and antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs) [2]. The study found that there was no consistent evidence to support the hypothesis that NSAIDs, including ibuprofen, reduce the efficacy of antidepressants.

However, it is important to note that the use of NSAIDs, including Advil, can have potential side effects and interactions with other medications. For example, NSAIDs can increase the risk of gastrointestinal bleeding, particularly in older adults or those taking anticoagulants or corticosteroids [3]. Additionally, NSAIDs can interact with certain antidepressants, such as SSRIs, and increase the risk of bleeding [4].

Therefore, it is essential to consult with a healthcare provider before taking Advil or any other NSAID while on antidepressants or any other medication. It is also important to follow the recommended dosage and duration of use for Advil and other NSAIDs to minimize the risk of side effects and interactions.

In summary, while there is no conclusive evidence to suggest that the regular use of Advil alters antidepressant efficacy, it is crucial to consult with a healthcare provider before taking Advil or any other NSAID while on antidepressants or any other medication.

Sources:

1. Mayo Clinic. (2021). Ibuprofen (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20069386?p=1>
2. Shelton, R. C., & Redfield, C. (2018). Nonsteroidal Anti-inflammatory Drugs and Antidepressant Response. Journal of Clinical Psychiatry, 79(6), 18r11852. <https://doi.org/10.4088/JCP.18r11852>
3. National Institute on Aging. (2021). Nonsteroidal Anti-inflammatory Drugs (NSAIDs). Retrieved from <https://www.nia.nih.gov/health/nonsteroidal-anti-inflammatory-drugs-nsaids>
4. Drugs.com. (2021). Ibuprofen Interactions. Retrieved from <https://www.drugs.com/drug-interactions/ibuprofen.html>
5. DrugPatentWatch.com. (n.d.). Ibuprofen. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen>