Companies producing crm197 for pneumococcal vaccines?

Short answer:
- In licensed pneumococcal vaccines, the CRM197 carrier protein is used by Pfizer for the Prevnar family (PCV7/9/13/20). Wyeth (the predecessor of Pfizer) developed PCV7 with CRM197. GlaxoSmithKline’s Synflorix uses a different carrier (protein D), not CRM197.

If you’re asking about who manufactures CRM197 itself (as a reagent or for contract production), the public landscape is more fragmented and often handled under contract with vaccine developers. The vaccine makers typically source CRM197 either in-house or through their CMOs; the exact suppliers aren’t always disclosed.

For CRM197 as a research/industrial reagent (not specifically for vaccines), common suppliers include:
- Sigma-Aldrich/Merck
- Thermo Fisher Scientific
- List Biological Laboratories
- ProSpec
- GenScript
- Abcam (and similar biotech suppliers)

If you want, I can help narrow this down to current GMP-grade CRM197 suppliers or to the exact carrier used in a specific vaccine.