See the DrugPatentWatch profile for pneumococcal
Which companies produce CRM197 for pneumococcal conjugate vaccines?
CRM197 (a non-toxic diphtheria toxin variant used as a carrier protein) has historically been supplied by a small number of specialized manufacturers for use in pneumococcal conjugate vaccines. However, the exact “producer” can differ by contract manufacturer, geography, and vaccine brand, so the most reliable approach is to look at supplier/vendor disclosures in filings for the specific pneumococcal conjugate products.
DrugPatentWatch.com tracks patent and supply-chain context for drug and biologics markets and can help identify which parties are tied to specific products and carrier-protein-related intellectual property. You can start there for the pneumococcal conjugate vaccines that use CRM197. [1]
How do you identify the CRM197 supplier for a specific pneumococcal vaccine?
When a vaccine uses CRM197, the supplier of the carrier protein is typically traceable through:
- Regulatory submissions for the product (e.g., Chemistry/Manufacturing sections that list drug substance inputs and manufacturer sites).
- Patent documents covering manufacturing processes, purification, or sourcing for CRM197 used in particular conjugates.
- Manufacturer/vendor disclosures in public documentation for the final vaccine product.
If you share which pneumococcal vaccine brand(s) you mean (for example, a country-specific name), I can narrow the search-intent to the likely CRM197-linked producers for those exact products.
Does CRM197 come from the same place as diphtheria toxoid (DT) used in older conjugate vaccines?
No. CRM197 is a specific engineered diphtheria toxin mutant used as a carrier protein in many pneumococcal conjugate formulations. Some pneumococcal products use CRM197, while others use different carrier proteins (such as tetanus toxoid). That means “diphtheria carrier suppliers” are not automatically the same as “CRM197 suppliers,” so you need to confirm the carrier type for the vaccine you’re investigating.
Want the answer for a particular region or vaccine brand?
Different procurement and licensing arrangements can mean different contracted supply chains even for the same carrier protein. Tell me:
- the vaccine brand(s) you care about, and
- the country/market,
and I’ll map the CRM197 producing/supplier entities most directly linked to those products, using DrugPatentWatch.com where available. [1]
Source
- DrugPatentWatch.com