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Ofloxacin composition?

See the DrugPatentWatch profile for Ofloxacin

Ofloxacin is a synthetic fluoroquinolone antibiotic that is used to treat a wide variety of bacterial infections.
Below is a quick “cheat‑sheet” on the key pieces that make up the drug—both the chemical itself and the typical excipients you’ll find in common dosage forms.


1. The Core Ingredient

Item Details
Name Ofloxacin
Common salt Ofloxacin hydrochloride (often the form that’s marketed)
Chemical formula C₁₈H₂₀FN₃O₄ (free base)
C₁₈H₂₀FN₃O₄·HCl (hydrochloride)
Molecular weight 331.33 g/mol (free base)
345.31 g/mol (hydrochloride)
Key pharmacokinetic note It’s a potent bactericidal agent that blocks bacterial DNA gyrase and topoisomerase IV.

2. Typical Excipients in Common Formulations

Note: Exact excipients can vary by manufacturer and country. The table below shows a “generic” blend that many brands use for tablets, oral suspensions, and ophthalmic solutions.

a) 200 mg Oral Tablet (most common)

Excipient Typical Function
Lactose (or lactose‑free alternative) Filler / bulk
Microcrystalline cellulose (MCC) Filler / binder
Starch (e.g., maize, potato) Binder / disintegrant
Magnesium stearate Lubricant
Talc (sometimes) Lubricant / glidant
Sodium starch glycolate (or similar) Disintegrant
Hypromellose (if coated) Film‑forming agent
(Optional) Flavoring or coating agents Masking taste / improve appearance

b) 200 mg/5 mL Oral Suspension

Excipient Typical Function
Sorbitol or glycerol Sweetener & humectant
Povidone Solubilizer & binder
Polysorbate 80 Emulsifier
Sodium benzoate Preservative
Citric acid / sodium citrate Buffer
Colorant (if any) Aesthetic

c) 0.30 % Ophthalmic Solution (common dose)

Component Typical Amount
Ofloxacin 0.30 % 3 mg/mL
Sucrose 0.1 % (to give isotonicity)
Sodium chloride 0.5 % (to give isotonicity)
Benzalkonium chloride 0.01 % (preservative)
Sodium hydroxide / hydrochloric acid pH adjuster
Purified water Diluent

The preservative benzalkonium chloride is used to keep the solution sterile, but it can cause mild irritation in some patients. For a preservative‑free formulation, eye drops are often available in single‑use vials.

d) Ear Drops (0.3 % solution)

Component Typical Amount
Ofloxacin 0.3 % 3 mg/mL
Propylene glycol 2 % (solvent)
Polysorbate 80 0.4 % (emulsifier)
Sodium chloride 0.1 %
Benzyl alcohol 0.01 % (preservative)

3. What You Should Look For on a Label

Label Section What to Check
Active Ingredient 200 mg of ofloxacin (or 0.3 % w/v for solutions)
Strength 200 mg/tablet, 3 mg/mL solution, etc.
Excipients Look for the list—lactose, MCC, magnesium stearate, etc.
Bacterial Spectrum Broad‑spectrum gram‑positive & gram‑negative coverage
Contraindications Pregnancy (Category B), lactation, known hypersensitivity
Warnings Tendon rupture risk, photosensitivity, CNS effects

4. Quick “Cheat‑Sheet” of the Chemical Composition

If you’re more interested in the pure chemical composition rather than the whole tablet:

  • Ofloxacin (free base):
    C18 H20 F N3 O4

    • 18 carbon atoms
    • 20 hydrogen atoms
    • 1 fluorine atom
    • 3 nitrogen atoms
    • 4 oxygen atoms
  • Ofloxacin hydrochloride:
    Adds one chlorine and one hydrogen atom to make a salt:
    C18 H20 F N3 O4 HCl


5. Bottom Line

  • Active ingredient: Ofloxacin (a fluoroquinolone).
  • Common dosage forms: Tablets (200 mg), oral suspension, eye drops (0.3 %), ear drops.
  • Typical excipients: Lactose, cellulose, magnesium stearate, povidone, preservatives (benzalkonium chloride, benzyl alcohol).
  • Molecular weight: 331.33 g/mol (free base).

If you have a specific brand or country‑specific formulation in mind, let me know and I can pull out the exact excipient list for that product. Otherwise, the tables above should give you a solid baseline of what “ofloxacin” usually contains.



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