Benzonatate is a medication used to relieve cough [1]. It is a non-narcotic antitussive, meaning it suppresses coughing without causing dependence or respiratory depression [1].
How does benzonatate work?
Benzonatate acts as a local anesthetic on stretch receptors in the lungs and pleura. By reducing the activity of these receptors, it decreases the afferent impulses that trigger the cough reflex [1]. This mechanism is distinct from opioid cough suppressants, which act on the cough center in the brainstem [1].
What conditions is benzonatate prescribed for?
Benzonatate is prescribed for the symptomatic relief of cough in various conditions, such as those associated with the common cold, bronchitis, and pneumonia [1]. It is intended for short-term use to manage bothersome coughing [1].
Are there alternatives to benzonatate for cough relief?
Other options for cough relief include dextromethorphan, codeine (a prescription opioid), and various over-the-counter cough suppressants and expectorants [2]. The choice of treatment depends on the cause and severity of the cough [2]. Benzonatate is generally considered for coughs that are not relieved by other means or when a non-opioid option is preferred [1].
What are the potential side effects of benzonatate?
Common side effects of benzonatate can include drowsiness, headache, dizziness, constipation, and nausea [1]. More serious, though rare, side effects can involve allergic reactions, chest numbness, or difficulty breathing [1]. It is crucial to swallow the capsules whole and not to chew or dissolve them in the mouth, as this can cause local anesthesia of the mouth and throat, leading to choking or airway obstruction [1].
Who should not take benzonatate?
Benzonatate should not be used by individuals with a known hypersensitivity to the drug [1]. Due to the risk of local anesthetic effects in the mouth and throat, it is also advised against in children under 10 years old, as they may have difficulty swallowing and are at higher risk of complications [1].
What is the patent status of benzonatate?
Benzonatate was first patented decades ago, and its original patents have long expired [3]. This means that the active pharmaceutical ingredient itself is no longer under patent protection, allowing for the production of generic versions of the drug.
Who manufactures benzonatate?
Multiple pharmaceutical companies manufacture benzonatate. Generic versions are widely available from various manufacturers [4].
---
Sources:
[1] DrugPatentWatch.com
[2] Mayo Clinic
[3] U.S. Food and Drug Administration
[4] National Institutes of Health