How long does trulance take to work?

How long does Trulance take to show effects?

The timeframe for Trulance (plecanatide) to produce noticeable effects can vary among individuals. Clinical trials have shown that patients may experience a bowel movement within 24 hours of taking the medication [1]. For some, improvements in abdominal pain and discomfort associated with chronic idiopathic constipation may become apparent within the first week of treatment [1].

What is Trulance used for?

Trulance is a prescription medication approved for the treatment of chronic idiopathic constipation (CIC) in adults [1]. It is also indicated for irritable bowel syndrome with constipation (IBS-C) in adult women [1].

How does Trulance work?

Trulance is an oral guanylate cyclase-C (GC-C) agonist. It works by activating the GC-C receptor in the lining of the intestine [1]. This activation increases the secretion of chloride and bicarbonate into the intestinal lumen, which draws water into the intestine and softens the stool [1]. Additionally, by stimulating fluid secretion and decreasing intestinal transit time, it helps to relieve the symptoms of constipation and abdominal pain [1].

When might Trulance be prescribed?

Physicians may consider Trulance for adults experiencing chronic constipation that has not responded to dietary changes and other lifestyle modifications [1]. It is also an option for adult women diagnosed with IBS-C, where constipation is the primary symptom [1].

What are the potential side effects of Trulance?

The most common side effect reported with Trulance is diarrhea [1]. Other possible side effects include abdominal pain, flatulence, and nausea [1]. Patients experiencing severe diarrhea or dehydration should contact their healthcare provider [1].

Can Trulance be used long-term?

Trulance is intended for the treatment of chronic constipation and IBS-C. Its long-term safety and efficacy have been evaluated in clinical studies, and it is generally considered for ongoing management of these conditions [1].

What are the alternatives to Trulance for constipation?

Besides Trulance, other treatment options for chronic idiopathic constipation and IBS-C may include other prescription medications such as lubiprostone, linaclotide, and prucalopride [2]. Over-the-counter options and lifestyle adjustments, including increased fiber intake and fluid consumption, are also common recommendations [2].

Sources:
1. https://www.trulance.com/
2. https://www.drugpatentwatch.com/