Cosentyx and the flu?

Is Cosentyx associated with a higher risk of flu complications?

Cosentyx, a medication for psoriasis and other autoimmune conditions, has raised concerns about its potential impact on patients' susceptibility to flu infections.

What are the flu risks associated with Cosentyx?

Research suggests that certain biologic medications, including Cosentyx, may increase the risk of infections, including the flu [1]. A study published in the Journal of Investigative Dermatology found that patients on Cosentyx had a higher rate of flu episodes compared to those on placebo [2]. However, a separate study published in the Journal of the American Academy of Dermatology found no association between Cosentyx use and flu rates [3].

Why the differing results?

Differences in study design, population, and duration may have contributed to the conflicting findings. Cosentyx's manufacturer states that the flu vaccine remains effective in patients taking Cosentyx [4]. Furthermore, patients on Cosentyx are advised to continue vaccination against the flu and other infections.

How does Cosentyx impact the immune system?

Cosentyx is an IL-17 inhibitor, which reduces inflammation by blocking the actions of a specific protein involved in immune responses. While this may provide benefits for patients with autoimmune conditions, it can also impair immune function and make individuals more susceptible to infections, including the flu [5].

Are there precautions patients can take?

To minimize the risk of flu complications, patients taking Cosentyx should:

1. Continue to receive annual flu vaccinations.
2. Practice good hygiene, including frequent handwashing and avoiding close contact with people who are sick.
3. Consider additional precautions, such as wearing masks in crowded areas or avoiding public gatherings during flu season.

What are the potential side effects of Cosentyx?

Common side effects of Cosentyx include upper respiratory tract infections, injection site reactions, and nasopharyngitis. Rare but serious side effects may include infections, such as pneumonia, and an increased risk of certain cancers [6].

Sources:

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321137/
[2] https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.16553
[3] https://jaad.org/article/S0190-9622(19)30549-4/fulltext
[4] https://www.cosentyx.com/us/patient/important-safety-information.html
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235553/
[6] https://www.cosentyx.com/us/patient/important-safety-information.html