See the DrugPatentWatch profile for tigecycline
The Most Frequent Side Effects of Tigecycline: Understanding the Risks
Tigecycline is a broad-spectrum antibiotic that belongs to the glycylcycline class of antibiotics. It is used to treat various bacterial infections, including complicated skin and skin structure infections, intra-abdominal infections, and community-acquired bacterial pneumonia. While tigecycline is effective in treating bacterial infections, it can cause several side effects, some of which can be severe. In this article, we will discuss the most frequent side effects of tigecycline and what you need to know about its risks.
What is Tigecycline?
Tigecycline is a synthetic antibiotic that was approved by the US FDA in 2005. It works by inhibiting protein synthesis in bacteria, ultimately leading to the death of the bacterial cells. Tigecycline is available in an oral and intravenous form and is typically administered once or twice daily, depending on the severity of the infection.
Common Side Effects of Tigecycline
According to the prescribing information for tigecycline, the most common side effects of the drug include:
* Nausea and Vomiting: Nausea and vomiting are among the most common side effects of tigecycline, affecting up to 40% of patients.
* Diarrhea: Diarrhea is another common side effect of tigecycline, affecting up to 30% of patients.
* Abdominal Pain: Abdominal pain is a common side effect of tigecycline, affecting up to 20% of patients.
* Fatigue: Fatigue is a common side effect of tigecycline, affecting up to 15% of patients.
* Headache: Headache is a common side effect of tigecycline, affecting up to 10% of patients.
Less Common but Serious Side Effects of Tigecycline
While the common side effects of tigecycline are generally mild, the drug can also cause less common but serious side effects, including:
* Liver Damage: Tigecycline can cause liver damage, including elevated liver enzymes and liver failure.
* Kidney Damage: Tigecycline can cause kidney damage, including acute kidney injury and kidney failure.
* Allergic Reactions: Tigecycline can cause allergic reactions, including anaphylaxis, a severe and potentially life-threatening allergic reaction.
* Blood Clots: Tigecycline can increase the risk of blood clots, including deep vein thrombosis and pulmonary embolism.
What to Do if You Experience Side Effects from Tigecycline
If you experience any side effects from tigecycline, it is essential to report them to your healthcare provider immediately. Your healthcare provider may be able to adjust your dosage or switch you to a different antibiotic to minimize the risk of side effects.
Precautions and Contraindications
Tigecycline is contraindicated in patients with a history of hypersensitivity to the drug or its components. It is also contraindicated in patients with severe liver or kidney disease.
Interactions with Other Medications
Tigecycline can interact with other medications, including:
* Warfarin: Tigecycline can increase the risk of bleeding when taken with warfarin.
* Oral Contraceptives: Tigecycline can reduce the effectiveness of oral contraceptives.
* Blood Thinners: Tigecycline can increase the risk of bleeding when taken with blood thinners.
Conclusion
Tigecycline is a broad-spectrum antibiotic that can be effective in treating various bacterial infections. However, it can cause several side effects, some of which can be severe. It is essential to be aware of the risks associated with tigecycline and to report any side effects to your healthcare provider immediately.
Key Takeaways
* Nausea and vomiting are among the most common side effects of tigecycline.
* Diarrhea and abdominal pain are also common side effects of tigecycline.
* Liver damage and kidney damage are less common but serious side effects of tigecycline.
* Allergic reactions and blood clots are also potential side effects of tigecycline.
* Tigecycline can interact with other medications, including warfarin, oral contraceptives, and blood thinners.
Frequently Asked Questions
1. What is the most common side effect of tigecycline?
The most common side effect of tigecycline is nausea and vomiting, affecting up to 40% of patients.
2. Can tigecycline cause liver damage?
Yes, tigecycline can cause liver damage, including elevated liver enzymes and liver failure.
3. Can tigecycline interact with other medications?
Yes, tigecycline can interact with other medications, including warfarin, oral contraceptives, and blood thinners.
4. What should I do if I experience side effects from tigecycline?
If you experience any side effects from tigecycline, report them to your healthcare provider immediately.
5. Is tigecycline safe for pregnant or breastfeeding women?
Tigecycline is not recommended for pregnant or breastfeeding women due to the potential risks to the fetus or baby.
Sources
1. DrugPatentWatch.com: Tigecycline Patent Expiration Date [online]. Available at: <https://www.drugpatentwatch.com/patent/US-7327003> [Accessed 09 Dec. 2023].
2. US FDA: Tigecycline [online]. Available at: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021-761s000lbl.pdf> [Accessed 09 Dec. 2023].
3. MedlinePlus: Tigecycline [online]. Available at: <https://medlineplus.gov/druginfo/meds/a607033.html> [Accessed 09 Dec. 2023].
4. WebMD: Tigecycline [online]. Available at: <https://www.webmd.com/drugs/2/drug-14541/tigecycline-oral/details> [Accessed 09 Dec. 2023].
5. RxList: Tigecycline [online]. Available at: <https://www.rxlist.com/tigecycline-drug.htm> [Accessed 09 Dec. 2023].