Ibuprofen, the active ingredient in Advil, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation. Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants used to manage depression, anxiety disorders, and some personality disorders.

According to the information provided, there is no inherent or well-documented interaction between Advil (ibuprofen) and SSRIs. However, it's important to note that both medications can affect the gastrointestinal (GI) system and increase the risk of gastrointestinal bleeding [1][2]. Concurrent use of NSAIDs and SSRIs may increase this risk [1].

Furthermore, both Advil and SSRIs are metabolized in the liver by cytochrome P450 enzymes [2][3]. While there is no specific information on the interaction between Advil and SSRIs regarding this metabolic pathway, it is essential to be cautious when combining medications metabolized by the same enzymes [2].

In summary, while there is no significant or well-documented interaction between Advil and SSRIs, it is crucial to be aware of the potential increased risk of gastrointestinal bleeding and the shared metabolic pathway. Consult a healthcare professional or pharmacist for personalized advice when combining these medications.

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/ADVIL>
[2] <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884264/>
[3] <https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/ssri-antidepressants/considerations/>