Why should advil be avoided with maoi antidepressants?

Taking Advil (ibuprofen) with MAOI (monoamine oxidase inhibitor) antidepressants can be hazardous due to a potential increase in serotonin levels in the brain [1]. MAOIs work by inhibiting the enzyme monoamine oxidase, which breaks down certain neurotransmitters, including serotonin [1]. When taken together with ibuprofen, the risk of serotonin syndrome, a rare but life-threatening condition, may rise.

Serotonin syndrome can cause symptoms such as confusion, agitation, rapid heart rate, changes in blood pressure, and loss of muscle coordination [1]. It is essential for individuals taking MAOIs to be cautious with all medications, including over-the-counter pain relievers like Advil [2].

According to the prescribing information for MAOI antidepressants, patients should avoid using ibuprofen or any other nonsteroidal anti-inflammatory drugs (NSAIDs) without consulting their healthcare provider [3].

If you are taking MAOIs and considering taking Advil, it is crucial to consult with your healthcare provider to discuss any potential risks and alternative pain management options.

Sources:

[1] Mayo Clinic. (n.d.). Serotonin syndrome. Retrieved from https://www.mayoclinic.org/symptoms/serotonin-syndrome/basics/definition/sym-20051077

[2] RxList. (n.d.). Nardil. Retrieved from https://www.rxlist.com/nardil-side-effects-drug-center.htm

[3] Lilly (Elanco). (2020). Phenelzine (Nardil) package insert. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e0c3c4b3-ecb5-4c8f-a1ec-2d6e7c8bb2f4