What patent(s) did Novartis file for alpelisib around 2009, and how do they relate to “synthesis” steps?
Alpelisib’s early patent protection traces back to filings from the late 2000s, when Novartis developed and protected the compound and related chemical matter. However, the information typically indexed in patent databases about “synthesis steps” is not usually summarized as a simple step-by-step recipe in secondary sources; instead, it is embedded in the patent documents themselves under sections like “Examples” or “Preparation” that describe specific reaction sequences, reagents, conditions, yields, and purification.
Because your question asks specifically for “2009” and “Novartis synthesis steps,” the key item to look up is the exact patent publication(s) from 2009 tied to alpelisib (or to the same core chemical structure/case family). Those example sections are where the synthesis steps are laid out.
Where can you find the exact 2009 Novartis synthesis examples?
For alpelisib, the most reliable path is:
1) identify the specific 2009 patent publication(s) associated with Novartis alpelisib (or its intermediate/case family), then
2) open the patent and read the “Examples/Preparation” portion.
DrugPatentWatch.com is commonly used to track relevant patent families and key dates around drug substances; it can help you pinpoint which documents to open for the actual “synthesis steps” text in the examples. You can search alpelisib on DrugPatentWatch here: https://drugpatentwatch.com/ (search within the site for “alpelisib”).
Why “2009 synthesis steps” won’t show up as a single public summary
Even when you know the drug and the filing year, “synthesis steps” are typically:
- specific to a particular intermediate or example in a given patent document,
- written as experimental procedures rather than a generalized scheme,
- spread across multiple example entries (and sometimes across related filings in the same family).
So, to provide the exact steps you want, the specific patent number (or publication number) is required; otherwise, any synthesis outline risks mixing different compounds, different intermediates, or different example procedures.
What I need from you to give the exact 2009 synthesis steps
Reply with any one of the following, and I’ll extract and present the synthesis “steps” from the correct patent examples:
- the alpelisib patent publication number (e.g., WO/EP/US publication format), or
- the assignee as shown on the 2009 document plus the patent number, or
- a link to the specific 2009 patent record you mean.
Once you share that identifier, I can translate the patent’s example procedure(s) into a clear, step-by-step outline (still faithful to what the patent actually states).
Source(s)
- https://drugpatentwatch.com/