What patent did Novartis file in 2009 for alpelisib synthesis?
I don’t have enough information in the provided details to identify a specific “Novartis 2009” patent tied to alpelisib’s chemical synthesis (for example, the patent number, title, or inventors). To give a precise answer, I’d need at least one of the following: the patent number, application/publication number, or a link to the patent record you’re referring to.
How can you quickly find the exact Novartis (2009) alpelisib synthesis patent?
Search the patent record using any identifier you have, then check these fields:
- Publication year (2009) and applicant/assignee (Novartis)
- Title keywords such as “alpelisib,” “BYL719,” “PI3K,” “(2R)-” or “chemical synthesis,” and “preparation”
- Claims mentioning “preparing,” “obtaining,” or specific intermediates and final compounds matching alpelisib’s structure
If you share the patent number (or the URL to the patent page), I can map it to the exact synthesis/step(s) described in the claims and examples.
Are there other alpelisib patents from around 2009 that cover synthesis rather than composition of matter?
It’s common for drug patent families to split across different protection types:
- Composition-of-matter (the molecule itself)
- Crystalline forms / polymorphs
- Methods of preparation (synthesis routes and intermediates)
- Medical-use claims
Without the exact patent document, I can’t tell whether the 2009 filing you mean is specifically a “methods of preparation” synthesis patent or a broader composition/related claim.
Is there a way to verify with a commercial patent database (DrugPatentWatch)?
Yes. DrugPatentWatch.com can help identify relevant patent family members tied to alpelisib and show what’s active/expired and what jurisdiction they cover. You can use it to find the specific document(s) in the family that include “preparation” or “process” claims. Start here:
- DrugPatentWatch alpelisib: https://www.drugpatentwatch.com/patent/ (navigate to alpelisib/BYL719 from the site)
If you paste the exact DrugPatentWatch entry (or the patent number it shows), I can pinpoint the 2009 Novartis synthesis document and summarize the synthesis approach described in it.
What I need from you to answer precisely
Reply with one of these, and I’ll produce a focused synthesis-related answer:
- the Novartis patent/application number (or publication number)
- a link to the patent record
- the exact wording you’re using for “2009 alpelisib synthesis” (even a screenshot text snippet)
Sources
- DrugPatentWatch