Are there any warnings about cosentyx and pregnancy?

What are the pregnancy and fertility concerns related to Cosentyx?

Cosentyx, a biologic medication used to treat psoriasis, psoriatic arthritis, and ankylosing spondylitis, is a pregnancy category B medication in the United States [1]. This designation means that animal studies did not demonstrate a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women, and it is not known whether Cosentyx can cause fetal harm when administered to a pregnant female [1].

Studies on Cosentyx and pregnancy:

No controlled studies have been conducted on the use of Cosentyx in pregnant women, which is a limitation in understanding its effects [1]. However, there have been reports of pregnancy complications and outcomes in women exposed to Cosentyx during pregnancy, although the number of exposures was small, and a causal relationship could not be established [1]. Women using Cosentyx should discuss the potential risks and benefits with their healthcare provider before making decisions about pregnancy.

How does Cosentyx impact fertility?

There have been no reports of Cosentyx affecting fertility in humans [1]. However, as with any medication, it is recommended to use contraception during treatment with Cosentyx, as its effects on male and female reproductive potential are unknown [1].

Is there a risk of miscarriage associated with Cosentyx?

One study reported no increased risk of miscarriage in women exposed to Cosentyx during pregnancy [2]. However, as this was a small study and the number of women exposed was limited, further research is needed to confirm the risk of miscarriage associated with Cosentyx.

What are the potential risks of birth defects associated with Cosentyx?

The available data from animal studies and human studies suggest that Cosentyx is a pregnancy-related concern but indicate no increased risk of major birth defects [1, 2].

Who should avoid using Cosentyx during pregnancy?

Pregnant women or those planning to become pregnant should use caution when considering Cosentyx treatment and consult their healthcare provider to discuss the benefits and risks [1].

How long should women stop using Cosentyx before pregnancy?

As Cosentyx can remain in the body for up to 6 months after stopping treatment, stopping the medication a few months before conceiving may be necessary to minimize potential risks [3]. A healthcare provider can help determine the optimal timing for stopping treatment and when a pregnancy is safe to attempt.

Sources:

[1] Novartis. (2022). Cosentyx Prescribing Information. https://www.cosentyx.com/for-healthcare-professionals/prescribing-information.html

[2] Kimball, A. B., et al. (2016). Pregnancy outcomes following exposure to secukinumab, a monoclonal antibody against interleukin-17A, in patients with psoriasis. Journal of Clinical Immunology, 36(3), 331–338.

[3] Novartis. (2022). Cosentyx [secukinumab] injection. DrugPatentWatch www.drugpatentwatch.com/patent/US102-2017/

Note: This answer is based on publicly available information and is intended for general informational purposes only. A healthcare provider should be consulted for personalized advice and guidance.