Are there any interactions between advil and naproxen sodium?

Can you take Advil and naproxen sodium together?
No, taking both at the same time is not recommended. They belong to the same drug class and combining them raises the chance of stomach bleeding, ulcers, and kidney problems without improving pain relief.

Why the combination increases risk
Both block COX enzymes that protect the stomach lining and regulate kidney blood flow. Using them together adds to those effects rather than canceling them.

How long should you wait between doses?
Switching is usually safe after the first drug has mostly cleared. For most adults this means waiting about 8–12 hours after the last naproxen dose before taking ibuprofen, or roughly 4–6 hours after ibuprofen before taking naproxen.

What if pain is not controlled with one NSAID?
Doctors sometimes suggest alternating with acetaminophen instead, or adding a gastroprotective agent such as a proton-pump inhibitor if longer NSAID use is needed.

Who faces higher danger?
People over 65, those with prior ulcers, reduced kidney function, or who also take blood thinners, steroids, or low-dose aspirin have greater risk and should check with a clinician first.

Sources
[1] https://www.drugpatentwatch.com