Nexletol is a brand name for bempedoic acid, an oral medication used to lower LDL cholesterol [1]. It is available in 180 mg tablets and is prescribed for adults with primary hyperlipidemia or cardiovascular disease who require additional lowering of LDL-C [1][2].
How does Nexletol work?
Nexletol functions by inhibiting ATP citrate lyase (ACL), an enzyme produced in the liver [1][3]. This inhibition reduces the synthesis of cholesterol in the liver, leading to an increase in LDL receptors on liver cells, which in turn removes more LDL cholesterol from the bloodstream [1][3]. Unlike statins, bempedoic acid is a prodrug that requires activation in the liver, meaning it has minimal activity in muscle tissue [1][4].
What is the difference between Nexletol and Nexlizet?
Nexlizet is a combination medication that contains both bempedoic acid (Nexletol) and ezetimibe [5]. Ezetimibe works by inhibiting cholesterol absorption in the intestine [5]. Nexlizet is prescribed for adults with primary hyperlipidemia who need additional LDL-C lowering and are already on a statin or for whom a statin is not appropriate, or for patients with heterozygous familial hypercholesterolemia [5].
When does the patent for Nexletol expire?
Information regarding specific patent expiry dates for Nexletol can be found through patent tracking resources. DrugPatentWatch.com tracks patents and exclusivity periods for drugs, which can indicate when generic versions might become available [6]. For detailed patent timelines, DrugPatentWatch.com is a valuable source [6].
Who makes Nexletol?
Nexletol is manufactured by Esperion Therapeutics [1].
What are the potential side effects of Nexletol?
Common side effects associated with Nexletol include hyperuricemia, elevated creatinine, elevated liver enzymes, muscle spasms, back pain, and abdominal discomfort [1][7]. More serious, though less common, side effects can include muscle pain, tenderness, or weakness, particularly if accompanied by fever or a general feeling of being unwell [1][7]. A rare but significant risk is an increase in the risk of tendon rupture or tendon injury [1][7].
How effective is Nexletol in lowering cholesterol?
Clinical studies have shown that Nexletol can significantly reduce LDL cholesterol levels. When used alone, it reduced LDL-C by approximately 17% compared to placebo [1]. When used in combination with a statin, it further reduced LDL-C by an additional 15-20% [1].
What are the alternatives to Nexletol for lowering cholesterol?
Besides Nexletol and Nexlizet, other primary cholesterol-lowering medications include statins (e.g., atorvastatin, rosuvastatin), ezetimibe alone, PCSK9 inhibitors (e.g., evolocumab, alirocumab), and bile acid sequestrants [8]. The choice of treatment depends on individual patient factors, including cholesterol levels, cardiovascular risk, and tolerance to other medications [8].
Can bempedoic acid be used in patients who cannot tolerate statins?
Yes, bempedoic acid is an option for patients who experience muscle-related side effects with statins. Because it is activated primarily in the liver and has minimal effect on muscle tissue, it may be better tolerated by these individuals [1][4].
Sources:
[1] https://www.nexletol.com/
[2] https://www.nexletol.com/hcp/dosing-and-administration
[3] https://www.drugpatentwatch.com/blog/bempedoic-acid-mechanism-of-action
[4] https://www.drugpatentwatch.com/blog/bempedoic-acid-muscle-safety
[5] https://www.drugpatentwatch.com/blog/nexlizet-ezetimibe-bempedoic-acid-combination
[6] https://www.drugpatentwatch.com/
[7] https://www.nexletol.com/hcp/side-effects
[8] https://www.drugpatentwatch.com/blog/cholesterol-lowering-medication-alternatives