Methotrexate is a medication used to treat various conditions, including cancer, rheumatoid arthritis, and psoriasis. While it is an effective medication, it can also have potential side effects, especially in seniors.

According to Drug Patent Watch [1], the most common side effects of methotrexate include nausea, vomiting, and diarrhea. Seniors may be more susceptible to these side effects due to age-related changes in the gastrointestinal tract. Additionally, methotrexate can cause liver damage, which can be more severe in seniors who already have liver problems. Seniors may also experience a decreased immune response, which can increase the risk of infections.

MedlinePlus [2] notes that methotrexate can also cause a decrease in the number of blood cells, including red blood cells, white blood cells, and platelets. This can lead to anemia, infections, and bleeding problems. Seniors may be more vulnerable to these side effects due to age-related changes in the bone marrow.

A study published in the Journal of the American Geriatrics Society [3] found that seniors taking methotrexate for rheumatoid arthritis had an increased risk of falls. This may be due to the medication's effect on balance and coordination.

In conclusion, while methotrexate can be an effective medication for treating various conditions, seniors may be more susceptible to its potential side effects. These can include gastrointestinal problems, liver damage, decreased immune response, anemia, bleeding problems, and an increased risk of falls. Seniors taking methotrexate should be closely monitored for these side effects and should report any concerns to their healthcare provider.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] https://medlineplus.gov/druginfo/meds/a682019.html
[3] https://pubmed.ncbi.nlm.nih.gov/24105334/