Yes, methotrexate can interact with other medications. Methotrexate is a prescription drug that is used to treat certain types of cancer, rheumatoid arthritis, and severe psoriasis. It works by slowing down the growth of certain cells in the body.

Methotrexate can interact with a number of other medications, which can affect the way it works or increase the risk of side effects. Some examples of medications that can interact with methotrexate include:

* Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen
* Aspirin
* Probenecid (Benemid)
* Certain antibiotics, such as tetracyclines, penicillins, and sulfonamides
* Certain anticonvulsant drugs, such as phenytoin (Dilantin) and phenobarbital
* Certain antidepressant drugs, such as fluoxetine (Prozac) and paroxetine (Paxil)
* Certain medications for diabetes, such as glipizide (Glucotrol) and glyburide (Micronase)
* Certain medications for heart disease, such as digoxin (Lanoxin) and furosemide (Lasix)
* Certain medications for high blood pressure, such as propranolol (Inderal) and verapamil (Calan, Isoptin)
* Certain medications for organ transplant rejection, such as azathioprine (Imuran) and cyclosporine (Neoral, Sandimmune)
* Certain medications for ulcers, such as cimetidine (Tagamet) and ranitidine (Zantac)
* Certain medications for viral infections, such as acyclovir (Zovirax) and ganciclovir (Cytovene)
* Certain vaccines, such as live virus vaccines

It is important to tell your doctor and pharmacist about all the medications you are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements, so they can check for potential interactions with methotrexate. You should also let them know if you are taking any of the medications listed above.

Sources:

1. [Methotrexate - Drug Patient Information (FDA)](https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/016952s051lbl.pdf)
2. [Methotrexate Interactions - Drugs.com](https://www.drugs.com/drug-interactions/methotrexate,methotrexate.html)
3. [Methotrexate - Mayo Clinic](https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/description/drg-20062831)
4. [Methotrexate - DrugBank](https://go.drugbank.com/drugs/DB00563)
5. [Methotrexate - DrugPatentWatch.com](https://www.drugpatentwatch.com/drugs/methotrexate)