What does the phrase “glimepiride synthesis sulfonamide isocyanate” refer to?
It sounds like you are looking for a specific patent disclosure or a reaction scheme used to make glimepiride that involves a sulfonamide and an isocyanate intermediate. Patents for glimepiride (or related processes) commonly describe how to build the drug’s core structures using intermediates such as sulfonamides (R–SO2–NH–) and isocyanates (R–NCO), then convert them into the final urea/carbamoyl-type functionality present in glimepiride.
To identify the exact “sulfonamide isocyanate” glimepiride synthesis and the correct patent, I need at least one more detail (for example: the patent number, the assignee/company name, a patent title fragment, or the jurisdiction: US/EP/WO).
Which patent covers glimepiride process chemistry using a sulfonamide–isocyanate step?
Glimepiride has been the subject of multiple patents over time—covering active ingredient claims, salt/polymorphs, and also manufacturing/process improvements. Without the specific patent identifier, I cannot reliably name the exact patent that matches your “sulfonamide isocyanate” description.
If you share any of the following, I can pinpoint the relevant patent and summarize what it says about the sulfonamide isocyanate step:
- Patent number (e.g., WO/US/EP…)
- Inventor or assignee (e.g., a specific generic or brand company)
- The exact intermediate names (the sulfonamide and isocyanate components)
- Any unique phrase from the document (even 10–20 words)
- Where you saw it (Google Patents link, PDF, or a screenshot)
When does the relevant glimepiride patent expire (and can generics launch before that)?
Patent expiry depends on which patent family you mean (drug substance vs process vs formulation) and also on jurisdiction-specific rules (term adjustments, extensions, patent term harmonization, and any regulatory exclusivities). Some process patents can expire earlier or later than substance patents, and exclusivity can be affected by how the claims are structured and enforced.
If you provide the specific patent/application (or at least the publication number), I can tell you what expiry it typically targets and what that usually means for generic or process work.
How to search for “glimepiride” patents with sulfonamide + isocyanate language
A practical way to locate the right document is to search by reaction keywords plus the drug name in patent databases:
- Search terms: glimepiride AND (sulfonamide OR SO2NH) AND (isocyanate OR NCO)
- Narrow by assignee (if known)
- Add “process for preparing” or “intermediate” keywords
- Check the “Examples” section in candidate patents for the actual sulfonamide/isocyanate transformation step
If you paste the patent text snippet where you see “sulfonamide” and “isocyanate,” I can help interpret what step it describes and which claim it supports.
What is the risk with relying on the “wrong” patent?
If multiple patents disclose similar chemistry, you can run into two problems:
- You might be looking at a patent that discusses the intermediate class but not the specific example that becomes glimepiride.
- Even if the process is similar, the legal coverage may depend on exact reagents, conditions, stereochemistry, or claim structure.
That’s why the exact patent number (or assignee/title snippet) matters before concluding “this is the” sulfonamide isocyanate patent.
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Quick next step
Send either (1) the patent number/publication number you have, or (2) a link/snippet showing the sulfonamide + isocyanate wording. Then I can identify the exact patent and summarize the synthesis step and what it claims.