Can Eliquis (apixaban) cause heartburn or acid reflux?
Heartburn is not a commonly highlighted side effect of Eliquis, but it can occur. Some people report upper stomach discomfort or indigestion after starting apixaban, which may feel like heartburn or reflux even if the label focuses more on bleeding-related or gastrointestinal symptoms.
If the symptoms are new after starting Eliquis, consider contacting the prescriber to discuss whether Eliquis is still the right choice and whether another cause (diet, other medications, reflux disease, infection, gastritis) is more likely.
What side effects from Eliquis might feel like heartburn?
Eliquis can cause stomach and digestive side effects in some patients, which can be perceived as heartburn. These include indigestion and nausea in some reports, and less commonly, more serious gastrointestinal problems.
When heartburn with Eliquis could be a warning sign
Because Eliquis increases bleeding risk, seek urgent care if you have symptoms that could indicate bleeding in the stomach or upper GI tract, especially if they include:
- black, tarry stools
- vomiting blood or material that looks like coffee grounds
- severe or worsening abdominal pain
- dizziness, fainting, or weakness
Do not try to “treat through” these signs with antacids alone.
What can patients do if they get reflux symptoms on Eliquis?
Talk with your clinician before changing medications. They may suggest an approach based on your symptoms and risk factors, such as:
- taking Eliquis exactly as prescribed
- reviewing other meds that worsen reflux
- considering reflux treatments that are compatible with apixaban (your pharmacist or prescriber can confirm)
What to check with your doctor or pharmacist
When you call, it helps to mention:
- when the heartburn started relative to starting Eliquis (or dose changes)
- how often it happens and what it feels like
- any red-flag symptoms (black stools, vomiting blood, severe pain)
- all other medicines you take, including NSAIDs (ibuprofen/naproxen), aspirin, steroids, or supplements, since these can increase GI risk
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