Lipitor is a brand name for the drug atorvastatin, which is used to lower cholesterol levels in the blood [1]. According to the sources provided, there is no direct interaction between Lipitor and over-the-counter painkillers. However, it is important to note that Lipitor can interact with other prescription medications, including ritonavir-boosted nirmatrelvir (Paxlovid), which is used to treat COVID-19 [2]. The interaction between Lipitor and ritonavir-boosted nirmatrelvir can lead to an increased risk of muscle pain and weakness, which are common side effects of Lipitor [2].

Additionally, it is important to be cautious when taking any medication, including over-the-counter painkillers, as they can interact with other medications and cause adverse effects. Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen can increase the risk of bleeding when taken with certain medications, including blood thinners [3]. Acetaminophen, another common painkiller, can cause liver damage when taken in high doses or when combined with alcohol [3].

In conclusion, there is no direct interaction between Lipitor and over-the-counter painkillers. However, it is important to be cautious when taking any medication and to talk to a healthcare provider about potential interactions and side effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/