Lipitor is a commonly prescribed medication used to lower cholesterol levels in the blood. It contains the active ingredient atorvastatin, which works by blocking the production of cholesterol in the liver [1]. Like all medications, Lipitor can cause side effects, and it is important to be aware of these potential risks before taking the medication.

According to the Mayo Clinic, some of the common side effects of Lipitor include muscle pain and weakness, headache, nausea, and diarrhea [2]. However, the risk of these side effects can be increased when Lipitor is taken with certain painkillers, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen. These painkillers can increase the risk of muscle damage and kidney problems when taken with Lipitor [2].

A study published in the Journal of Pharmacy Practice and Research found that the use of NSAIDs with statins like Lipitor can increase the risk of muscle damage and kidney problems. The study recommends that patients taking Lipitor should avoid using NSAIDs, or use them with caution and under the guidance of a healthcare professional [3].

In conclusion, Lipitor can cause side effects, including muscle pain and weakness, and taking it with certain painkillers like NSAIDs can increase the risk of muscle damage and kidney problems. Patients taking Lipitor should be aware of these potential risks and should speak with their healthcare provider before taking any new medications or supplements [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/