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See the DrugPatentWatch profile for pregnyl
How does Pregnyl affect testosterone levels in men? Pregnyl is a brand of human chorionic gonadotropin (hCG) that mimics luteinizing hormone. It stimulates the testes to produce testosterone naturally rather than supplying it from outside. Studies show men with hypogonadism who received hCG injections saw significant rises in serum testosterone within weeks. What is the recommended dosing schedule for Pregnyl? Typical protocols use 1,500–5,000 IU injected two to three times per week. Dose and frequency are adjusted based on bloodwork showing testosterone, estradiol, and sperm parameters. Doctors commonly keep patients on maintenance doses for months or years. Does Pregnyl preserve fertility while raising testosterone? Yes. hCG keeps the testes active and prevents the testicular shrinkage and sperm reduction that occurs with straight testosterone replacement. Patients and physicians often choose Pregnyl alone or combined with enclomiphene or clomiphene when fertility is a priority. What side effects do patients report most often? Common complaints include injection-site pain, gynecomastia from elevated estrogen, mood swings, and fluid retention. Some men develop antibodies to hCG after long-term use, causing responsiveness to drop. How does Pregnyl compare to standard testosterone injections? Standard testosterone injections supply the hormone directly. Pregnyl prompts the body to make its own. Both raise testosterone to normal ranges, but Pregnyl maintains testicular size and function. Price per month is usually higher for hCG protocols than for testosterone cypionate. When does Pregnyl’s patent expire? Pregnyl has been marketed for decades. Its core compound hCG is no longer protected by basic composition-of-matter patents. Generic versions are available from multiple manufacturers.
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