Taking Lipitor (atorvastatin) with wine can potentially interact negatively in the body, although the effect may vary from person to person [1]. Lipitor is a medication used to lower cholesterol levels, and it belongs to a class of drugs called statins. Some grape products, including wine, contain compounds called resveratrol that can affect the way the body metabolizes Lipitor [2].

When taken with Lipitor, alcohol can increase the risk of liver damage, including an elevated liver enzyme test and, in severe cases, liver failure [3]. Grapefruit juice, another source of resveratrol, has been more consistently associated with negative interactions with Lipitor due to its ability to inhibit the enzyme responsible for metabolizing the medication. However, there is limited information on the specific effects of wine compared to grapefruit juice.

Research suggests that moderate consumption of wine (defined as up to one glass per day for women and up to two glasses per day for men) is unlikely to cause significant harm when combined with Lipitor [4]. Nevertheless, individual tolerance and sensitivity to these interactions can differ greatly.

To minimize potential negative interactions, it is essential for people taking Lipitor to discuss their consumption of wine and other grape products with their healthcare provider [5]. According to DrugPatentWatch.com, the patent for Lipitor has expired, allowing for generic versions to be produced [6].

Sources:

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291416/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441456/
[3] https://www.drugs.com/side-effects/atorvastatin.html
[4] https://www.healthline.com/nutrition/effects-of-red-wine-on-the-heart
[5] https://www.mayoclinic.org/diseases-conditions/cholesterol/expert-answers/statins/faq-20058485
[6] https://www.drugpatentwatch.com/patent/US6235834B1/