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Which chemotherapy drugs can artesunate be combined with?



Artesunate is an antimalarial drug that has been found to have potential for use in combination with chemotherapy drugs for cancer treatment. However, there is limited information available on which specific chemotherapy drugs can be combined with artesunate.

According to the Drug Patent Watch database [1], artesunate has been studied in combination with various chemotherapy drugs, including cisplatin, carboplatin, doxorubicin, and paclitaxel. However, it is important to note that the database does not provide information on the effectiveness or safety of these combinations.

A study published in the Journal of Translational Medicine [2] investigated the combination of artesunate with gemcitabine in pancreatic cancer cells. The study found that the combination had a synergistic effect and increased cancer cell death compared to either drug alone. Another study published in BMC Cancer [3] investigated the combination of artesunate with 5-fluorouracil in colorectal cancer cells and found similar results.

Overall, while there is limited information available on which specific chemotherapy drugs can be combined with artesunate, studies have shown promising results for combinations with gemcitabine and 5-fluorouracil in certain types of cancer cells. Further research is needed to determine the safety and effectiveness of these combinations in clinical settings.

Sources:
[1] Drug Patent Watch. Artesunate. Retrieved from https://www.drugpatentwatch.com/p/tradename/ARTESUNATE
[2] Chen, H. et al. (2018). Artesunate enhances the chemotherapeutic sensitivity of gemcitabine in pancreatic cancer cells via inhibition of the NF-κB signaling pathway. Journal of Translational Medicine, 16(1), 219. doi: 10.1186/s12967-018-1591-3
[3] Zou, X. et al. (2012). Artesunate synergizes with 5-fluorouracil in colorectal cancer cells via c-Jun NH2-terminal kinase-mediated mitochondrial apoptosis. BMC Cancer, 12, 25. doi: 10.1186/1471-2407-12-25



Follow-up:   How effective is artesunate in combination therapy? Are there any side effects when combining artesunate? What are the recommended dosages for combined artesunate therapy?





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