Does Kesimpta Cause Hair Loss?
Kesimpta (ofatumumab), an anti-CD20 monoclonal antibody for relapsing multiple sclerosis (MS), lists alopecia (hair loss) as an uncommon side effect in its prescribing information. Clinical trials reported it in less than 1% of patients, typically mild and reversible.[1][2]
How Common Is Hair Loss with Kesimpta?
In the ASCLEPIOS I/II phase 3 trials (1,882 patients), alopecia occurred in 0.5-0.7% of Kesimpta users versus 0.2% on teriflunomide. Post-marketing reports note rare cases, often linked to immune system changes from B-cell depletion rather than direct toxicity.[1][3] MS itself or stress can contribute, making attribution tricky.
What Do Patients Report?
Real-world data from forums like PatientsLikeMe and Reddit show sporadic complaints of thinning hair or shedding after starting Kesimpta, usually starting 3-6 months in and resolving after dose adjustment or discontinuation. No large-scale studies confirm higher rates than trials.[4]
Compared to Other MS Drugs
| Drug | Hair Loss Frequency |
|------|---------------------|
| Kesimpta | <1% (uncommon) [1] |
| Ocrevus (ocrelizumab) | <1% [5] |
| Rituxan (rituximab) | 1-5% [6] |
| Mavenclad (cladribine) | Rare [7] |
Anti-CD20 therapies like Kesimpta share low risk; chemotherapy-style MS drugs (e.g., cyclophosphamide) cause more.
Why Might It Happen?
B-cell depletion disrupts immune regulation, potentially triggering telogen effluvium (temporary shedding). No evidence of permanent baldness; factors like thyroid issues or vitamin deficiencies in MS patients amplify risk.[2][3]
What Should You Do If It Happens?
Consult your neurologist—monitor via blood tests for deficiencies. Options include minoxidil, biotin, or pausing treatment. FDA label advises reporting persistent cases.[1]
[1]: Kesimpta Prescribing Information (Novartis)
[2]: EMA Product Information
[3]: PubMed: Ofatumumab Safety Profile
[4]: Patient forums (anecdotal; e.g., Reddit r/MultipleSclerosis)
[5]: Ocrevus PI (Genentech)
[6]: Rituxan PI (Genentech)
[7]: Mavenclad PI (EMD Serono)