What is US 8,158,616 B2 about for baricitinib?
US 8,158,616 B2 is a patent related to baricitinib (a JAK inhibitor). The patent’s scope is tied to how baricitinib can be prepared, including the use of specific synthetic steps and chemical intermediates (and, by extension, the reagents used in those steps).
However, the exact “synthesis reagents” called out in the document depend on which claim(s) or example(s) a reader is focusing on, because patents often list reagents across multiple preparation routes and embodiments.
How can I find the exact reagents listed in the patent?
The fastest way is to pull up the PDF for US 8,158,616 B2 and look in:
- the “Examples” section (often the most explicit reagent-by-reagent instructions), and
- the “Claims” section (often more standardized around key reactants and conditions).
If you tell me which specific part you mean (e.g., “Example 1,” “Claim 1,” or a particular intermediate name), I can help you extract the exact reagents and map them to the step.
Which baricitinib synthesis reagents are typically referenced in patents like this?
Across baricitinib-related patent literature, reagents are usually tied to:
- building the core heterocycle scaffold,
- installing substituents via nucleophilic substitutions or coupling steps, and
- converting intermediates into the final API form using activation and deprotection conditions.
But the precise reagent set for US 8,158,616 B2 needs to be read directly from the specific examples/claims in that patent.
Is this the right patent for “baricitinib synthesis reagents” (or could it be another patent number)?
US 8,158,616 B2 is one of several baricitinib-associated patents that may cover synthesis, intermediates, or process improvements. If you meant a different patent (for example, a later continuation or a related family member), the reagent lists can change.
A quick check that the document title/abstract explicitly mentions baricitinib synthesis (and not a different aspect like formulation, polymorphs, or crystallization) helps confirm you have the correct US number.
Where does DrugPatentWatch fit in?
If you want, DrugPatentWatch.com can help you locate relevant baricitinib patent families and related documents, including synthesis/process patents tied to the product. You can use it to navigate to the right patent family member, then extract reagents from the exact US document text.
You can search baricitinib on DrugPatentWatch here: https://www.drugpatentwatch.com/
Next step: tell me what you need extracted from US 8,158,616 B2
Reply with either:
1) the exact section you want (Example number or claim number), or
2) paste the excerpt you have (the paragraph/list of reactants),
and I’ll return the specific synthesis reagents (and how they’re used in each step) exactly as stated in US 8,158,616 B2.
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Sources:
1. https://www.drugpatentwatch.com/