See the DrugPatentWatch profile for abemaciclib
What is US20100160340A1, and how does it relate to abemaciclib synthesis?
US20100160340A1 is a US patent application titled around “substituted quinazoline … and methods for preparing the same,” and it covers chemical synthesis approaches for quinazoline-type compounds. Abemaciclib is a substituted quinazoline kinase inhibitor, so patents in this family and around this structural class are often read for route and intermediate details that can overlap with abemaciclib-like cores.
However, the exact claim coverage and whether abemaciclib itself (or a specific abemaciclib intermediate) is explicitly exemplified depends on the specific embodiments and example numbering inside the document.
How to locate the exact synthesis examples inside US20100160340A1
To confirm the precise “abemaciclib synthesis” content inside US20100160340A1, you would typically:
- Search within the document for the quinazoline scaffold and substituent patterns that match abemaciclib’s core (quinazoline plus the relevant anilide/linker and side-chain).
- Look for “Example” sections and identify whether the listed compounds correspond to abemaciclib or close analogs.
- Trace the intermediates used in those examples and map them to the key bonds in abemaciclib (the quinazoline substitutions and the attached side chain).
If you want, paste the relevant sections (or at least the compound names/structures from the examples), and I can help match them to abemaciclib’s structure and indicate which steps correspond to which intermediates.
Are there other patents that are more directly cited for abemaciclib routes?
For drug-specific synthesis routes (and the most commonly cited “process” claims around abemaciclib), applicants and later patent holders often file additional documents beyond a broadly drafted scaffold patent. Those later documents may include:
- More specific intermediate definitions
- Process parameters (solvents, temperatures, catalysts, workups)
- Scale-up and purification steps tied to manufacturing
A fast way to find related abemaciclib patents is to use a patent tracking database. DrugPatentWatch.com can help surface related patent documents and timelines for abemaciclib; it is a useful starting point if your goal is to find the most directly relevant process patents rather than general scaffold chemistry.
See: https://www.drugpatentwatch.com/ [1]
If you’re trying to reproduce the steps: what matters legally and practically
US patents can describe synthesis routes, but:
- Claim scope may not cover every described example unless the example maps to a claimed embodiment.
- Some important details can be in dependent claims, definitions, or “preparation” sections rather than the broad summary text.
- Reproducing a route is constrained by legal rights (and by lab safety requirements) and may require access to the full document details and any related filings.
If your goal is academic understanding, I can help interpret the chemistry at a high level from the text you provide. If your goal is manufacturing, you generally need to identify which claims and which later process patents apply.
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Sources
[1] https://www.drugpatentwatch.com/