Who holds patents for oliceridine, and what is the “spiro synthesis” angle?
Patents related to oliceridine exist across multiple areas, including the drug substance and its manufacturing. “Spiro synthesis” typically refers to patent claims that cover how the spirocyclic core of oliceridine is constructed during chemical synthesis. Those claims can be found under assignee names connected to the oliceridine R&D and commercialization chain, which may include the original developer and later rights holders. The specific patent(s) that mention “spiro” or “spirocyclic” steps depend on the jurisdiction and publication family.
To identify the exact “oliceridine spiro synthesis” patent you mean, you need at least one of the following: the patent number, application/publication number, assignee name, or where you saw the term “spiro synthesis” (e.g., a patent database entry, a litigation document, or an Orange Book/eligibility filing).
How do you search for the exact “spiro synthesis” patent (fast and reliably)?
If you’re trying to locate the precise spiro-related manufacturing claims, the most effective approach is to combine the drug name with structural and process keywords in a patent database.
Look for combinations like:
- “oliceridine” plus “spiro”, “spirocyclic”, “spiro ring”, or “spiro[” (sometimes used in chemical naming)
- “manufacture” or “process for preparing” plus “oliceridine”
- “intermediate” plus the spiro-specific intermediate name(s) if you have them
Then filter by:
- Country (US, EP, WO)
- Publication date (often several years before market entry for substance/process families)
- Assignee (the company behind oliceridine’s chemistry/process)
If you share the country (US vs WO/EP) or any identifier you already have, I can point you to the right publication family structure and what to look for in the claims.
What patent numbers or publications should you check for oliceridine manufacturing/process claims?
Oliceridine patent sets usually split into categories that can include:
- Drug substance (composition/solid form)
- Process for making the active ingredient (chemical synthesis steps)
- Intermediates used in the synthesis
- Methods of treatment (less relevant to “spiro synthesis” unless the question is actually about claims tied to use)
“Spiro synthesis” claims generally fall under process and intermediate families. Those are the families you’d prioritize if your question is about manufacturing scope, design-around options, or regulatory/ANDA/other market-entry challenges.
Can design-arounds avoid the spiro synthesis claims?
Yes, depending on claim breadth. Process patents often cover specific reaction sequences, specific reagents/conditions, specific intermediates, or a combination. A competitor might try to:
- Use a different route to form the spiro bond
- Build the spiro ring via an alternative cyclization strategy
- Change key intermediates or key steps so the specific claimed steps are not performed as written
Whether a design-around works depends on the exact claim language (not the label like “spiro synthesis”). If you provide the claim text or the patent/publication number, the likely scope and what would or wouldn’t infringe can be assessed much more precisely.
How long do these patents last (and what could extend exclusivity)?
For manufacturing/process patents, the term is typically tied to filing dates and national law (e.g., up to 20 years from the earliest effective non-provisional filing, with possible adjustments). Separate exclusivities may apply at the product level (regulatory exclusivity rather than patent term), which can affect when generic or competitor versions can enter even if certain patents expire.
To answer this for the “spiro synthesis” patent specifically, you’d need the earliest priority date (from the publication) and the jurisdiction(s) you care about.
What litigation or challenge signals would point to the “spiro synthesis” patent?
In practice, “spiro synthesis” process patents become important when:
- A generic/manufacturer files a market entry challenge that lists patents (or carved-out process steps) they dispute
- A lawsuit claims infringement based on the manufacturing route to the active ingredient
- The patentee asserts that a competitor’s synthesis performs the claimed steps or uses claimed intermediates
Those signals usually appear in public court filings or in patent listing/challenge documents. If you tell me the case name, docket, or jurisdiction, I can help you map which patent family is being asserted.
What I need from you to give the exact patent(s)
The phrase “Oliceridine spiro synthesis patent” is not specific enough to identify one document. Provide any one of the following, and I’ll return the exact patent/publication(s) and what the spiro synthesis claims cover:
- Patent number or publication number (WO/US/EP)
- Assignee/company name
- The jurisdiction you care about (US vs WO vs EP)
- A link or screenshot text from where you saw “spiro synthesis”
- The chemical intermediate name mentioned in the patent entry
Sources
No sources were provided in your prompt, and I don’t have access to external patent databases from here without an identifier (e.g., a publication number or link). If you share a patent/publication number or link, I can extract and summarize the “spiro synthesis” portion accurately.