Advil, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. According to Drug Patent Watch [1], there is no known interaction between Advil and antidepressants. However, a study by Harvard Health Publishing [2] suggests that popular painkillers like Advil may interfere with antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs). The study found that NSAIDs may reduce the effectiveness of SSRIs, leading to worsening symptoms of depression. The National Health Service (NHS) [3] also warns that SSRIs may increase the risk of bleeding if taken with NSAIDs like Advil, which can also increase the risk of bleeding.

It is important to note that while there is no known interaction between Advil and antidepressants, patients should still exercise caution when taking these medications together. Patients should always consult with their healthcare provider before taking any new medication, including over-the-counter drugs like Advil. It is also important to inform healthcare providers of all medications, including supplements and vitamins, being taken to avoid any potential interactions or adverse effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.health.harvard.edu/press_releases/caution-popular-painkillers-may-interfere-with-antidepressants
[3] https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/ssri-antidepressants/considerations/