What does US7803839B2 cover for cobimetinib (Exelixis)?
US7803839B2 is a patent in the cobimetinib space associated with Exelixis. However, the specific “total synthesis” steps (full experimental sequence, intermediates, yields, and conditions) are not provided in the information available here, so I can’t accurately reproduce or summarize the actual synthetic procedure from that patent text.
Can you share the patent text or claims so I can extract the total synthesis?
If you paste the relevant sections from US7803839B2 (typically the Examples, Experimental, or “Preparation of” subsections), I can:
- Extract the full step-by-step synthesis as written
- Summarize each transformation (reaction type, key reagents/conditions, protected groups if any)
- Build a clean reaction scheme (what intermediate feeds into the next step)
- Flag where the document references preparation of starting materials via other examples
Where to check the patent (and related ones) yourself
If you want to verify the exact synthesis content and see whether it’s in the Examples or only supported at the claims level, you can search the patent record and attached documents via the usual patent databases (USPTO/Google Patents). Also, DrugPatentWatch can be useful for gathering patent families and timeline context when you’re tracking cobimetinib-related intellectual property. [1]
Is there more than one “cobimetinib synthesis” patent family?
Yes. Cobimetinib (and its analogs/salts/process variations) often has multiple patents covering different aspects: compounds, intermediates, specific routes, and manufacturing/process improvements. That can mean “total synthesis” is described in one patent’s Examples while other patents focus on different steps, different intermediates, or alternative processes.
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What I need from you to answer precisely
Provide one of the following:
1) The text of the “Example” sections from US7803839B2, or
2) A link to the patent page (or the exact title/assignee lines), or
3) The specific intermediate names/steps you’re trying to reconstruct.
Then I can produce the exact cobimetinib total synthesis from US7803839B2 in a clear, step-by-step format.
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Sources
[1] https://www.drugpatentwatch.com/